Long-term follow-up of a randomized clinical trial comparing glycemic excursion minimization (GEM) to weight loss (WL) in the management of type 2 diabetes
| العنوان: | Long-term follow-up of a randomized clinical trial comparing glycemic excursion minimization (GEM) to weight loss (WL) in the management of type 2 diabetes |
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| المؤلفون: | Anthony L. McCall, Mark R. Conaway, Matthew Moncrief, Tamara K. Oser, Daniel J. Cox |
| المصدر: | BMJ Open Diabetes Research & Care, Vol 9, Iss 2 (2021) BMJ Open Diabetes Research & Care |
| بيانات النشر: | BMJ Publishing Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Research design, Adult, Blood Glucose, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, Diseases of the endocrine glands. Clinical endocrinology, law.invention, Randomized controlled trial, Weight loss, law, Diabetes mellitus, Internal medicine, Weight Loss, Medicine, Humans, Glycemic, Aged, Aged, 80 and over, business.industry, Blood Glucose Self-Monitoring, life style, Middle Aged, medicine.disease, RC648-665, Regimen, Diabetes Mellitus, Type 2, type 2, diabetes mellitus, glycated hemoglobin A, Clinical care/Education/Nutrition, hyperglycemia, medicine.symptom, business, Body mass index, Follow-Up Studies |
| الوصف: | IntroductionWe previously reported the physical, psychological and behavioral 3-month post-treatment results of a randomized controlled trial comparing glycemic excursion minimization (GEM) versus conventional weight loss (WL) therapy in the management of type 2 diabetes (T2D). GEM is a paradigm shift in the lifestyle management of T2D that focuses on reducing postnutrient glucose excursions, rather than reducing weight. We now present the 13-month follow-up results.Research design and methodsThe initial study sample of 172 were 30–80 years old, had T2D for ≤10 years, an HbA1c ≥6.8% (51 mmol/mol), and were not using insulin. Participants were randomized to 6 hours of group treatment, either to WL or one of three versions of GEM. GEM groups differed in degree of blood glucose (BG) feedback provided during treatment: no recommended feedback, systematic capillary BG feedback before and after nutrient intake and physical activity, or continuous glucose monitoring. Since these GEM groups did not differ in pre-post improvement they were combined for initial and current analyses. Of those who completed the 3-month postassessment, 100% and 96% of the WL and GEM participants completed the 13-month follow-up assessment.ResultsPre to follow-up within-group comparisons indicated WL participants sustained improvement in body mass index (BMI) (−0.9±1.4, p=0.001). GEM participants continued to benefit in their HbA1c (−0.5±1.4, pConclusionsWhile WL sustained improvement in BMI, GEM sustained benefits across a broad range of physical, behavioral and psychological parameters, beneficial for clinicians and adults with T2D. This may be especially relevant for primary care physicians who manage about 90% of patients with T2D.Trial registration numberNCT03196895. |
| اللغة: | English |
| تدمد: | 2052-4897 0319-6895 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2482439ac4be3bab83a024a624790aTest https://drc.bmj.com/content/9/2/e002403.fullTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7e2482439ac4be3bab83a024a624790a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20524897 03196895 |
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