Open-label pilot study of romiplostim for thrombocytopenia after autologous hematopoietic cell transplantation
| العنوان: | Open-label pilot study of romiplostim for thrombocytopenia after autologous hematopoietic cell transplantation |
|---|---|
| المؤلفون: | Michael Scordo, Leah J. Gilbert, Danielle M. Hanley, Jessica R. Flynn, Sean M. Devlin, Linh K. Nguyen, Josel D. Ruiz, Gunjan L. Shah, Craig S. Sauter, David J. Chung, Heather J. Landau, Oscar B. Lahoud, Richard J. Lin, Parastoo B. Dahi, Miguel-Angel Perales, Sergio A. Giralt, Gerald A. Soff |
| المصدر: | Blood Advances. 7:1536-1544 |
| بيانات النشر: | American Society of Hematology, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Hematology |
| الوصف: | There are no standard treatments to prevent or hasten the recovery from severe conditioning-regimen–induced thrombocytopenia occurring after autologous hematopoietic cell transplantation (auto-HCT). We conducted an open-label, single-arm pilot study of romiplostim, a thrombopoietin receptor agonist, to enhance platelet recovery in patients with multiple myeloma or lymphoma undergoing auto-HCT. All patients were treated weekly with romiplostim starting day +1 after auto-HCT until the platelet count was >50 × 109/L without transfusion. Compared with contemporary retrospective data from romiplostim-naïve patients (N = 853), romiplostim-treated patients (N = 59) had a similar median number of days of grade 4 thrombocytopenia or days requiring transfusions, time to platelet engraftment, and number of platelets transfusions during the auto-HCT. However, romiplostim-treated patients had enhanced platelet recovery to normal values beginning at approximately day +15. In matched cohort multivariable analyses, romiplostim treatment was associated with higher platelet counts by an average of 40 × 109/L (95% confidence interval (CI) (14, 67), P = .003) and 118 × 109/L (95% CI [84, 152], P |
| تدمد: | 2473-9537 2473-9529 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e244dffe40a0b1da09124d3c7ed78c3Test https://doi.org/10.1182/bloodadvances.2022007838Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7e244dffe40a0b1da09124d3c7ed78c3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24739537 24739529 |
|---|