Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling?: The MeDALL hypothesis
| العنوان: | Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling?: The MeDALL hypothesis |
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| المؤلفون: | Cezmi A. Akdis, Monique Mommers, Claus Bachert, Emilie Burte, Hamida Hammad, Marta Benet, Moises A. Calderon, Erik Melén, A. Bedbrook, Torsten Zuberbier, Leda Chatzi, U. Gehrig, Rachel Nadif, Johann Pellet, Dieter Maier, J. Just, Mariona Pinart, Jean Bousquet, Niklas Andersson, Stephane Ballereau, C. Tischer, L. von Hertzen, Angela Neubauer, M. Akdis, Esben Eller, Valérie Siroux, Judith Garcia-Aymerich, Kai-Håkon Carlsen, Anna Bergström, Sam Oddie, Carsten Bindslev-Jensen, Joachim Heinrich, Christian Lupinek, Anna Asarnoj, Natalia Ballardini, Thomas Keil, Jordi Sunyer, Stefano Guerra, Nathanaël Lemonnier, Charles Auffray, Henriette A. Smit, Manolis Kogevinas, C. Hohman, M. van Hage, John Wright, Josep M. Antó, Magnus Wickman, K. C. Lødrup Carlsen, Tari Haahtela, Daniela Porta, Anne Cambon-Thomsen, M P Fantini, Marjan Kerkhof, Isabelle Momas, Susanne Lau, Pascal Demoly, S. Palkonen, I. Skrindo, Syed Hasan Arshad, Y. Saes, I. Annesi-Maesano, M. Torrent, Francesco Forastiere, Rudolf Valenta, Martijn C. Nawijn, G. De Carlo, Gerard H. Koppelman, Carel Thijs, Bart N. Lambrecht, Bert Brunekreef, Inger Kull, Dirkje S. Postma, Marek L. Kowalski, Isabelle Pin |
| المساهمون: | Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], University of Helsinki, Ghent University Hospital, European Institute for Systems Biology and Medicine (EISBM), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, University of Crete [Heraklion] (UOC), IMIM-Hospital del Mar, Generalitat de Catalunya, Karolinska Institutet [Stockholm], Epidémiologie Environnementale : Impact Sanitaire des Pollutions (EA 4064), Université Paris Descartes - Paris 5 (UPD5), Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, European Synchrotron Radiation Facility (ESRF), University Hospital of Cologne [Cologne], Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Service d'Allergologie pédiatrique [CHU Trousseau], CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), The Institute of Environmental Medicine [Stockholm] (IMM), CHU Grenoble, Epidemiologie, RS: CAPHRI School for Public Health and Primary Care, RS: CAPHRI - R5 - Optimising Patient Care, LS IRAS EEPI ME (Milieu epidemiologie), Dep IRAS, Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), J Bousquet, JM Anto, M Wickman, T Keil, R Valenta, T Haahtela, K Lodrup Carlsen, M van Hage, C Akdi, C Bachert, M Akdi, C Auffray, I Annesi-Maesano, C Bindslev-Jensen, A Cambon-Thomsen, KH Carlsen, L Chatzi, F Forastiere, J Garcia-Aymerich, U Gehrig, S Guerra, J Heinrich, GH Koppelman, ML Kowalski, B Lambrecht, C Lupinek, D Maier, E Melén, I Moma, S Palkonen, M Pinart, D Postma, V Siroux, HA Smit, J Sunyer, J Wright, T Zuberbier, SH Arshad, R Nadif, C Thij, N Anderson, A Arsanoj, N Balardini, S Ballereau, A Bedbrook, M Benet, A Bergstrom, B Brunekreef, E Burte, M Calderon, G De Carlo, P Demoly, E Eller, MP Fantini, H Hammad, C Hohman, J Just, M Kerkhof, M Kogevina, I Kull, S Lau, N Lemonnier, M Mommer, M Nawijn, A Neubauer, S Oddie, J Pellet, I Pin, D Porta, Y Sae, I Skrindo, CG Tischer, M Torrent, L von Hertzen, Groningen Research Institute for Asthma and COPD (GRIAC) |
| المصدر: | Allergy, 70(9), 1062. Blackwell Publishing Ltd Allergy Allergy, Wiley, 2015, 70 (9), pp.1062--1078. ⟨10.1111/all.12637⟩ Allergy, 70(9), 1062-1078. Wiley-Blackwell Allergy 70, 1062-1078 (2015) Bousquet, J, Anto, J M, Wickman, M, Keil, T, Valenta, R, Haahtela, T, Lodrup Carlsen, K, van Hage, M, Akdis, C, Bachert, C, Akdis, M, Auffray, C, Annesi-Maesano, I, Bindslev-Jensen, C, Cambon-Thomsen, A, Carlsen, K H, Chatzi, L, Forastiere, F, Garcia-Aymerich, J, Gehrig, U, Guerra, S, Heinrich, J, Koppelman, G H, Kowalski, M L, Lambrecht, B, Lupinek, C, Maier, D, Melén, E, Momas, I, Palkonen, S, Pinart, M, Postma, D, Siroux, V, Smit, H A, Sunyer, J, Wright, J, Zuberbier, T, Arshad, S H, Nadif, R, Thijs, C, Andersson, N, Asarnoj, A, Ballardini, N, Ballereau, S, Bedbrook, A, Benet, M, Bergstrom, A, Brunekreef, B, Burte, E, Calderon, M, De Carlo, G, Demoly, P, Eller, E, Fantini, M P, Hammad, H, Hohman, C, Just, J, Kerkhof, M, Kogevinas, M, Kull, I, Lau, S, Lemonnier, N, Mommers, M, Nawijn, M, Neubauer, A, Oddie, S, Pellet, J, Pin, I, Porta, D, Saes, Y, Skrindo, I, Tischer, C G, Torrent, M & von Hertzen, L 2015, ' Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling? The MeDALL hypothesis ', Allergy: European Journal of Allergy and Clinical Immunology, Supplement, vol. 70, no. 9, pp. 1062–1078 . https://doi.org/10.1111/all.12637Test Allergy, 70(9), 1062. Wiley-Blackwell |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Allergy, Ige, Asthma, Atopic Dermatitis, Polysensitization, Rhinitis, [SDV]Life Sciences [q-bio], Genome-wide association study, Review, Comorbidity, Immunoglobulin E, 0302 clinical medicine, Antibody Specificity, Pregnancy, Hypersensitivity/epidemiology, Immunology and Allergy, HEALTH-SURVEY-I, Family history, GENERAL-POPULATION SAMPLE, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, biology, atopic dermatitis, ACTIVE EOSINOPHILIC ESOPHAGITIS, Atopic dermatitis, EPITHELIAL BARRIER FUNCTION, 3. Good health, ALLERGY, Phenotype, Prenatal Exposure Delayed Effects, Antibody Specificity/immunology, Immunoglobulin E/immunology, Female, IgE, Signal Transduction, Immunology, SOYBEAN EPIDEMIC ASTHMA, Allergens/immunology, 03 medical and health sciences, rhinitis, Journal Article, Hypersensitivity, medicine, Humans, Multimorbidity, Genetic Predisposition to Disease, Epigenetics, GENOME-WIDE ASSOCIATION, SERUM IMMUNOGLOBULIN-E, 030304 developmental biology, SKIN PRICK TEST, business.industry, Allergens, asthma, medicine.disease, ORAL FOOD CHALLENGES, 030228 respiratory system, polysensitization, biology.protein, Immunization, business, SEVERE ATOPIC-DERMATITIS |
| الوصف: | Allergic diseases (asthma, rhinitis and atopic dermatitis) are complex. They are associated with allergen-specific IgE and non-allergic mechanisms that may coexist in the same patient. In addition, these diseases tend to cluster and patients present concomitant or consecutive diseases (multimorbidity). IgE sensitization should be considered as a quantitative trait. Important clinical and immunological differences exist between mono or polysensitized subjects. Multimorbidities of allergic diseases share common causal mechanisms that are only partly IgE-mediated. Persistence of allergic diseases over time is associated with multimorbidity and/or IgE polysensitization. The importance of the family history of allergy may decrease with age. This review puts forward the hypothesis that allergic multimorbidities and IgE polysensitization are associated and related to the persistence or re-occurrence of foetal Type 2 signalling. Asthma, rhinitis and atopic dermatitis are manifestations of a common systemic immune imbalance (mesodermal origin) with specific patterns of remodelling (ectodermal or endodermal origin). This paper proposes a new classification of IgE-mediated allergic diseases that allows the definition of novel phenotypes in order to (i) better understand genetic and epigenetic mechanisms, (ii) better stratify allergic preschool children for prognosis, and (iii) propose novel strategies of treatment and prevention. |
| وصف الملف: | image/pdf; application/pdf; ELETTRONICO |
| اللغة: | English |
| تدمد: | 0105-4538 1398-9995 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d2c861b7e2b35356c51d725f467c35cTest https://dspace.library.uu.nl/handle/1874/329493Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7d2c861b7e2b35356c51d725f467c35c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01054538 13989995 |
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