Mechanisms of Cerebral Microbleeds
| العنوان: | Mechanisms of Cerebral Microbleeds |
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| المؤلفون: | Chuo Fang, Ronald C. Kim, Jeffrey Kim, Lara C. Wadi, Mark Fisher, Maria M. Corrada, Mher Mahoney Grigoryan, Annlia Paganini-Hill |
| المصدر: | J Neuropathol Exp Neurol Journal of neuropathology and experimental neurology, vol 42, iss 2 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cingulate cortex, Male, Pathology, Arteriosclerosis, retrospective study, very elderly, claudin 5, Autopsy, 0302 clinical medicine, Basal ganglia, 80 and over, 2.1 Biological and endogenous factors, Aetiology, Blood-brain barrier, Aged, 80 and over, 0303 health sciences, quantitative analysis, adult, General Medicine, Immunohistochemistry, female, medicine.anatomical_structure, priority journal, Neurology, Neurological, brain hemorrhage, histopathology, Female, ferric ferrocyanide, Erratum, medicine.medical_specialty, Histology, brain region, Clinical Sciences, Neuropathology, Blood–brain barrier, Article, Pathology and Forensic Medicine, 03 medical and health sciences, Cellular and Molecular Neuroscience, Cerebral microhemorrhage, medicine, Middle frontal gyrus, Humans, human, Pathological, Aged, 030304 developmental biology, Cerebral Hemorrhage, Retrospective Studies, neuropathology, Neurology & Neurosurgery, business.industry, Neurosciences, immunohistology, Original Articles, medicine.disease, major clinical study, human tissue, Brain Disorders, smooth muscle actin, fibrinogen, Neurology (clinical), business, 030217 neurology & neurosurgery |
| الوصف: | Cerebral microbleeds (CMB) are a common MRI finding, representing underlying cerebral microhemorrhages (CMH). The etiology of CMB and microhemorrhages is obscure. We conducted a pathological investigation of CMH, combining standard and immunohistological analyses of postmortem human brains. We analyzed 5 brain regions (middle frontal gyrus, occipital pole, rostral cingulate cortex, caudal cingulate cortex, and basal ganglia) of 76 brain bank subjects (mean age ± SE 90 ± 1.4 years). Prussian blue positivity, used as an index of CMH, was subjected to quantitative analysis for all 5 brain regions. Brains from the top and bottom quartiles (n = 19 each) were compared for quantitative immunohistological findings of smooth muscle actin, claudin-5, and fibrinogen, and for Sclerosis Index (SI) (a measure of arteriolar remodeling). Brains in the top quartile (i.e. with most extensive CMH) had significantly higher SI in the 5 brain regions combined (0.379 ± 0.007 vs 0.355 ± 0.008; p |
| وصف الملف: | application/pdf |
| تدمد: | 1554-6578 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8e19dd60b76cdbb044be2be1b94b24Test https://pubmed.ncbi.nlm.nih.gov/33463693Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7c8e19dd60b76cdbb044be2be1b94b24 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15546578 |
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