Taurine up‐regulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma
| العنوان: | Taurine up‐regulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma |
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| المؤلفون: | Meng-Han Wu, Hsiang-Cheng Chi, Ya-Hui Huang, Chau-Ting Yeh, I-Hsiao Chung, Kwang-Huei Lin, Chung-Ying Tsai, Ching-Ying Chen, Mei-Ling Cheng, Yang-Hsiang Lin |
| المصدر: | Hepatology. 67:188-203 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Carcinoma, Hepatocellular, Taurine, Biology, Real-Time Polymerase Chain Reaction, Bioinformatics, Sensitivity and Specificity, Metastasis, 03 medical and health sciences, Cell Line, Tumor, microRNA, medicine, Humans, Glycolysis, Neoplasm Metastasis, Regulation of gene expression, Hepatology, Biopsy, Needle, Liver Neoplasms, Cell migration, medicine.disease, Immunohistochemistry, Up-Regulation, Gene Expression Regulation, Neoplastic, MicroRNAs, 030104 developmental biology, Anaerobic glycolysis, Tumor progression, Cancer cell, Cancer research, Female, RNA, Long Noncoding, Signal Transduction |
| الوصف: | Cancer cells display altered glucose metabolism characterized by a preference for aerobic glycolysis. The aerobic glycolytic phenotype of hepatocellular carcinoma (HCC) is often correlated with tumor progression and poorer clinical outcomes. However, the issue of whether glycolytic metabolism influences metastasis in HCC remains unclear. In the current study, we showed that knockdown of taurine up-regulated gene 1 (TUG1) induces marked inhibition of cell migration, invasion, and glycolysis through suppression of microRNA (miR)-455-3p. MiR-455-3p, which is transcriptionally repressed by p21, directly targets the 3' untranslated region of adenosine monophosphate-activated protein kinase subunit beta 2 (AMPKβ2). The TUG1/miR-455-3p/AMPKβ2 axis regulates cell growth, metastasis, and glycolysis through regulation of hexokinase 2 (HK2). TUG1 is clearly associated with HK2 overexpression and unfavorable prognosis in HCC patients. Conclusion Our data collectively highlight that novel regulatory associations among TUG1, miR-455-3p, AMPKβ2, and HK2 are an important determinant of glycolytic metabolism and metastasis in HCC cells and support the potential utility of targeting TUG1/HK2 as a therapeutic strategy for HCC. (Hepatology 2018;67:188-203). |
| تدمد: | 1527-3350 0270-9139 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c80ee5c4a7ceb9ac17a2d530b89e9a7Test https://doi.org/10.1002/hep.29462Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....7c80ee5c4a7ceb9ac17a2d530b89e9a7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15273350 02709139 |
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