The clinicopathological study of lung cancer concealed in end-stage of interstitial lung disease
| العنوان: | The clinicopathological study of lung cancer concealed in end-stage of interstitial lung disease |
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| المؤلفون: | Bei Wang, Huang Chen, Dingrong Zhong, Jie Li, Fei Xiao, Xiaoyan Zhang, Lei Yang, Chaoyang Liang |
| المصدر: | Translational Cancer Research |
| بيانات النشر: | AME Publishing Company, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Cancer Research, Pathology, medicine.medical_specialty, medicine.medical_treatment, lung cancer concealed in end-stage of interstitial lung disease (LC-CES-ILD), H&E stain, behavioral disciplines and activities, Idiopathic pulmonary fibrosis, lung transplantation, medicine, Lung transplantation, Radiology, Nuclear Medicine and imaging, Interstitial lung disease (ILD), Lung cancer, lung cancer (LC), Molecular pathology, business.industry, Interstitial lung disease, respiratory system, medicine.disease, respiratory tract diseases, Oncology, Immunohistochemistry, Adenocarcinoma, Original Article, business |
| الوصف: | Background: Most of the patients with interstitial lung disease (ILD) complicated with lung cancer (ILD- LC) showed non-specific clinical manifestations. This study is to explore the incidence of lung cancer concealed in the end-stage of interstitial lung disease (LC-CES-ILD). Methods: A total of 154 cases of lung transplantation from March 2017 to December 2018 were studied retrospectively, of which 7 cases were found to be LC-CES-ILD. Serum tumor biomarkers were examined. HE and immunohistochemical staining were performed for the tumor tissue after the operation. Lung cancer (LC) drive gene was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Results: The percentage of male patients with idiopathic pulmonary fibrosis (IPF) was 44.81%. The expression of all tumor biomarkers was significantly increased in 6 patients with LC-CES-ILD. After operation, apparent destruction of lung tissue structure was observed in 7 patients, and honeycomb appearance could be seen in some areas. After HE staining, 4 cases of acinar type and 2 cases of mucinous adenocarcinoma were found. The results of molecular pathology showed that only one case of mucinous adenocarcinoma had KRAS mutation, and no mutation of LC co-driving gene was found in the rest of the cases. Conclusions: It is necessary to detect the lung tissue of patients with end-stage ILD, which were probably correlated with the occurrence of LC concealed, before lung transplantation. |
| تدمد: | 2219-6803 2218-676X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3705a878e8920357207434db9533a8Test https://doi.org/10.21037/tcr.2019.11.36Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7c3705a878e8920357207434db9533a8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22196803 2218676X |
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