Effect of Selenium Nanoparticles on Carbon Tetrachloride-Induced Hepatotoxicity in the Swiss Albino Rats
| العنوان: | Effect of Selenium Nanoparticles on Carbon Tetrachloride-Induced Hepatotoxicity in the Swiss Albino Rats |
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| المؤلفون: | Ashraf M. Ahmed, Hossam Ebaid, Ahmed Rady, Iftekhar Hassan, Mohamed A. Habila, Ibrahim M. Alhazza, Jameel Al-Tamimi |
| المصدر: | Applied Sciences, Vol 11, Iss 3044, p 3044 (2021) Applied Sciences Volume 11 Issue 7 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, liver functions, medicine.medical_specialty, hepatotoxicity, CCl4, medicine.medical_treatment, Liquid paraffin, Intraperitoneal injection, Aspartate transaminase, digestive system, lcsh:Technology, lcsh:Chemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Lactate dehydrogenase, Internal medicine, selenium nanoparticles, medicine, oxidative stress, General Materials Science, Instrumentation, lcsh:QH301-705.5, Fluid Flow and Transfer Processes, Liver injury, biology, lcsh:T, Process Chemistry and Technology, General Engineering, Malondialdehyde, medicine.disease, digestive system diseases, lcsh:QC1-999, Computer Science Applications, 030104 developmental biology, Endocrinology, chemistry, lcsh:Biology (General), lcsh:QD1-999, lcsh:TA1-2040, 030220 oncology & carcinogenesis, Carbon tetrachloride, biology.protein, Liver function, lcsh:Engineering (General). Civil engineering (General), lcsh:Physics |
| الوصف: | Background: This study investigated selenium nanoparticles’ protective effects (SE-NPs) against carbon tetrachloride (CCl4)-induced hepatic injury in rats. Methods: Rats were divided into four groups (n = 8). Group 1 rats received the vehicle solution only. Group 2 received a single intraperitoneal injection of 1 mL/kg CCl4 in liquid paraffin (1:1 v/v). Group 3 was treated with SE-NPs (2.5 mg/kg) twice a week for three weeks before receiving CCl4 challenge. Oxidative stress, liver function, liver histopathology and serum lipid levels were evaluated. Results: Plasma concentrations of aspartate transaminase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), urea, creatinine, malondialdehyde (MDA) and the toxicity marker, lactate dehydrogenase (LDH), were significantly elevated in rats treated with CCl4 compared to the controls. CCl4 also caused a significant decline in liver glutathione (GSH) concentration. SE-NP pretreatment significantly improved the level of AST, urea, creatinine, MDA, LDH, and GSH in the CCl4-injected rats towards the control levels. Conclusions: SE-NPs restored both liver function and hepatic structure in CCl4 treated rats. SE-NPs exhibit an ability to counter markers of liver injury induced by CCl4 and restore oxidative stability to lipid profiles and liver structure and function. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2076-3417 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf33c132c87c7ba3072a2466a393e88Test https://www.mdpi.com/2076-3417/11/7/3044Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7bf33c132c87c7ba3072a2466a393e88 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20763417 |
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