التفاصيل البيبلوغرافية
العنوان:
Data from Improvements in Radiographic Progression-Free Survival Stratified by ERG Gene Status in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Abiraterone Acetate
المؤلفون:
Charles J. Ryan , Howard I. Scher , Dana E. Rathkopf , Kathy Zelinsky , Deborah S. Ricci , Thian Kheoh , Thomas W. Griffin , Arturo Molina , Weimin Li , Alfons J.M. van den Eertwegh , Dirk Schrijvers , Anthony M. Joshua , Som D. Mukherjee , Karim Fizazi , Christopher J. Logothetis , Johann S. de Bono , Gerhardt Attard
بيانات النشر:
American Association for Cancer Research (AACR), 2023.
سنة النشر:
2023
الوصف:
Purpose: Gene fusions leading to androgen receptor–modulated ERG overexpression occur in up to 70% of metastatic castration-resistant prostate cancers (mCRPC). We assessed the association between ERG rearrangement status and clinical benefit from abiraterone acetate.Experimental Design: COU-AA-302 is a phase III trial comparing abiraterone acetate and prednisone versus prednisone in chemotherapy-naïve mCRPC. ERG status was evaluated by FISH on archival tumors. End points included radiographic progression-free survival (rPFS), time to PSA progression (TTPP), rate of ≥50% PSA decline from baseline, and overall survival (OS). Cox regression was used to evaluate association with time-to-event measures and Cochran–Mantel–Haenszel for PSA response.Results: ERG status was defined for 348 of 1,088 intention-to-treat patients. ERG was rearranged in 121 of 348 patients with confirmed ERG status (35%). Cancers with an ERG fusion secondary to deletion of 21q22 and increased copy number of fusion sequences (class 2+ Edel) had a greater improvement in rPFS after abiraterone acetate and prednisone [22 vs. 5.4 months; HR (95% confidence interval, CI), 0.31 (0.15–0.68); P = 0.0033] than cancers with no ERG fusion [16.7 vs. 8.3 months; 0.53 (0.38–0.74); P = 0.0002] or other classes of ERG rearrangement. There was also greater benefit in this subgroup for TTPP.Conclusions: Both ERG-rearranged and wild-type cancers had a significant improvement in rPFS with abiraterone acetate and prednisone in the COU-AA-302 trial. However, our data suggest that 2+ Edel cancers, accounting for 15% of all mCRPC patients and previously associated with a worse outcome, derived the greatest benefit. Clin Cancer Res; 21(7); 1621–7. ©2015 AACR.
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb62fe791cbcdf4eef4f79d30be7792Test https://doi.org/10.1158/1078-0432.c.6524364Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....7bb62fe791cbcdf4eef4f79d30be7792
قاعدة البيانات:
OpenAIRE
