Outcomes after retreatment with MAPK inhibitors and immune checkpoint inhibitors in melanoma patients
| العنوان: | Outcomes after retreatment with MAPK inhibitors and immune checkpoint inhibitors in melanoma patients |
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| المؤلفون: | Cornelia Mauch, Oana D. Persa |
| المصدر: | Future Oncology. 17:3809-3817 |
| بيانات النشر: | Future Medicine Ltd, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, MAPK/ERK pathway, Oncology, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Immune checkpoint inhibitors, education, 03 medical and health sciences, 0302 clinical medicine, Elevated lactate dehydrogenase, Internal medicine, medicine, Humans, Immune Checkpoint Inhibitors, Melanoma, Protein Kinase Inhibitors, Aged, Retrospective Studies, Advanced melanoma, Chemotherapy, Univariate analysis, business.industry, General Medicine, Middle Aged, medicine.disease, humanities, Treatment Outcome, 030104 developmental biology, MAPK Inhibitors, 030220 oncology & carcinogenesis, Retreatment, Female, business |
| الوصف: | Background: When patients with advanced melanoma progress after MAPK inhibitor (MAPKI) and immune checkpoint inhibitor (ICI) treatment, they can either undergo chemotherapy or rechallenge with previously used treatments. Methods: The outcomes of 48 patients retreated with MAPKIs and 50 patients retreated with ICIs following progression were retrospectively analyzed. Results: Upon retreatment with MAPKIs, the disease control rate was 60%. Univariate analysis of possible risk factors associated with short progression-free survival upon MAPKI treatment showed elevated LDH to be associated with decreased progression-free survival. Disease control rate after ICI retreatment was 24%. Melanoma of unknown primary was associated with prolonged progression-free survival upon ICI retreatment. Conclusion: Retreatment with MAPKIs or ICIs is a feasible option for patients with advanced melanoma. |
| تدمد: | 1744-8301 1479-6694 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb6088a468b29625321685c0107e2b3Test https://doi.org/10.2217/fon-2021-0446Test |
| رقم الانضمام: | edsair.doi.dedup.....7bb6088a468b29625321685c0107e2b3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17448301 14796694 |
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