Cardiovascular risk factors are associated with venous thromboembolism
| العنوان: | Cardiovascular risk factors are associated with venous thromboembolism |
|---|---|
| المؤلفون: | Gregson, John, Kaptoge, Stephen, Bolton, Thomas, Pennells, Lisa, Willeit, Peter, Burgess, Stephen, Bell, Steven, Sweeting, Michael, Rimm, Eric B., Kabrhel, Christopher, Zoller, Bengt, Assmann, Gerd, Gudnason, Vilmundur, Folsom, Aaron R., Arndt, Volker, Fletcher, Astrid, Norman, Paul E., Nordestgaard, Borge G., Kitamura, Akihiko, Mahmoodi, Bakhtawar K., Whincup, Peter H., Knuiman, Matthew, Salomaa, Veikko, Meisinger, Christa, Koenig, Wolfgang, Kavousi, Maryam, Voelzke, Henry, Cooper, Jackie A., Ninomiya, Toshiharu, Casiglia, Edoardo, Rodriguez, Beatriz, Ben-Shlomo, Yoav, Despres, Jean-Pierre, Simons, Leon, Barrett-Connor, Elizabeth, Bjorkelund, Cecilia, Notdurfter, Marlene, Kromhout, Daan, Price, Jackie, Sutherland, Susan E., Sundstroem, Johan, Kauhanen, Jussi, Gallacher, John, Beulens, Joline W. J., Dankner, Rachel, Cooper, Cyrus, Giampaoli, Simona, Deen, Jason F., Gomez de la Camara, Agustin, Kuller, Lewis H., Rosengren, Annika, Svensson, Peter J., Nagel, Dorothea, Crespo, Carlos J., Brenner, Hermann, Albertorio-Diaz, Juan R., Atkins, Robert, Brunner, Eric J., Shipley, Martin, Njolstad, Inger, Lawlor, Deborah A., van der Schouw, Yvonne T., Selmer, Randi Marie, Trevisan, Maurizio, Verschuren, W. M. Monique, Greenland, Philip, Wassertheil-Smoller, Sylvia, Lowe, Gordon D. O., Wood, Angela M., Butterworth, Adam S., Thompson, Simon G., Danesh, John, Di Angelantonio, Emanuele, Meade, Tom, Rosamond, Wayne, Whitsel, Eric, Cushman, Mary, Barr, Elizabeth L. M., Shaw, Jonathan E., Zimmet, Paul Z., Kiechl, Stefan, Weger, Siegfried, Willeit, Johann, Amuzu, Antoinette, Dale, Caroline, Casas, Juan P., Tikhonoff, Valerie, Nietert, Paul, Tybjaerg-Hansen, Anne, Frikke-Schmidt, Ruth, Jensen, Gorm B., Lora Pablos, David, Cancelas Navia, Pilar, McLachlan, Stela, Schoettker, Ben, Saum, Kai-Uwe, Holleczek, Bernd, Ariansen, Inger, Meyer, Haakon E., Haheim, Lise Lund, Vartiainen, Erkki, Jousilahti, Pekka, Harald, Kennet, Wilhelmsen, Lars, Dennison, Elaine, Syddall, Holly, Westbury, Leo, Flicker, Leon, Hankey, Graeme J., Golledge, Jonathan, Doi, Yasufumi, Kiyohara, Yutaka, Elders, Petra, Stehouwer, Coen, Jensen, Majken, Iso, Hiroyasu, Yamagishi, Kazumasa, Sudhir, Kurl, Tuomainen, Tomi-Pekka, Salonen, Jukka T., Boer, Jolanda M. A., Blokstra, Anneke, Melander, Olle, Nilsson, Peter M., Engstrom, Gunnar, Palmieri, Luigi, Vanuzzo, Diego, Peters, Annette, Thorand, Barbara, Heier, Margit, Hu, Frank B., Manson, JoAnn E., Meijer, Karina, Gansevoort, Ron T., Schulte, Helmut, Sluijs, Ivonne, Cantin, Bernard, Lamarche, Benoit, Dagenais, Gilles R., McEvoy, Linda, Laughlin, Gail, Daniels, Lori B., Aspelund, Thor, Gudmundsson, Elias Freyr, Thorsson, Bolli, Leening, Maarten J. G., Ikram, M. Arfan, Franco, Oscar H., Tunstall-Pedoe, Hugh, Werner, Andre, Devereux, Richard, Jolly, Stacey, Smith, George Davey, Can, Gunay, Yuksel, Husniye, Altay, Servet, Ingelsson, Martin, Giedraitis, Vilmantas, Claessen, Heiner, Rothenbacher, Dietrich, Parikh, Nisha, I, Eaton, Charles, Kivimaki, Mika, Feskens, Edith, Geleijnse, Johanna M., Spackman, Sarah, Walker, Matthew |
| المساهمون: | Cardiovascular Centre (CVC), Groningen Kidney Center (GKC), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Kaptoge, Stephen [0000-0002-1155-4872], Pennells, Lisa [0000-0002-8594-3061], Burgess, Stephen [0000-0001-5365-8760], Bell, Steven [0000-0001-6774-3149], Sweeting, Michael [0000-0003-0980-8965], Wood, Angela [0000-0002-7937-304X], Butterworth, Adam [0000-0002-6915-9015], Danesh, John [0000-0003-1158-6791], Di Angelantonio, Emanuele [0000-0001-8776-6719], Apollo - University of Cambridge Repository, Epidemiology, ACS - Diabetes & metabolism, APH - Health Behaviors & Chronic Diseases, Epidemiology and Data Science, ACS - Heart failure & arrhythmias |
| المصدر: | JAMA Cardiol. 4, 163-173 (2019) JAMA Cardiology, 4(2), 163-173 Gregson, J, Kaptoge, S, Bolton, T, Pennells, L, Willeit, P, Burgess, S, Bell, S, Sweeting, M, Rimm, E B, Kabrhel, C, Zöller, B, Assmann, G, Gudnason, V, Folsom, A R, Arndt, V, Fletcher, A, Norman, P E, Nordestgaard, B G, Kitamura, A, Mahmoodi, B K, Whincup, P H, Knuiman, M, Salomaa, V, Meisinger, C, Koenig, W, Kavousi, M, Völzke, H, Cooper, J A, Ninomiya, T, Casiglia, E, Rodriguez, B, Ben-Shlomo, Y, Després, J P, Simons, L, Barrett-Connor, E, Björkelund, C, Notdurfter, M, Kromhout, D, Price, J, Sutherland, S E, Sundström, J, Kauhanen, J, Gallacher, J, Beulens, J W J, Dankner, R, Cooper, C, Giampaoli, S, Deen, J F, Gómez De La Cámara, A, Kuller, L H, Rosengren, A, Svensson, P J, Nagel, D, Crespo, C J, Brenner, H, Albertorio-Diaz, J R, Atkins, R, Brunner, E J, Shipley, M, Njølstad, I, Lawlor, D A, Van Der Schouw, Y T, Selmer, R M, Trevisan, M, Verschuren, W M M, Greenland, P, Wassertheil-Smoller, S, Lowe, G D O, Wood, A M, Butterworth, A S, Thompson, S G, Danesh, J, Di Angelantonio, E & Meade, T 2019, ' Cardiovascular Risk Factors Associated With Venous Thromboembolism ', JAMA Cardiology, vol. 4, no. 2, pp. 163-173 . https://doi.org/10.1001/jamacardio.2018.4537Test Jama cardiology, 4(2), 163-173. AMER MEDICAL ASSOC JAMA Cardiology 4 (2019) 2 Gregson, J, Kaptoge, S, Bolton, T, Pennells, L, Willeit, P, Burgess, S, Bell, S, Sweeting, M, Rimm, E B, Kabrhel, C, Zöller, B, Assmann, G, Gudnason, V, Folsom, A R, Arndt, V, Fletcher, A, Norman, P E, Nordestgaard, B R G, Kitamura, A, Mahmoodi, B K, Whincup, P H, Knuiman, M, Salomaa, V, Meisinger, C, Koenig, W, Kavousi, M, Völzke, H, Cooper, J A, Ninomiya, T, Casiglia, E, Rodriguez, B, Ben-Shlomo, Y, Després, J-P, Simons, L, Barrett-Connor, E, Björkelund, C, Notdurfter, M, Kromhout, D, Price, J, Sutherland, S E, Sundström, J, Kauhanen, J, Gallacher, J, Beulens, J W J, Dankner, R, Cooper, C, Giampaoli, S, Deen, J F, Gómez de la Cámara, A, Kuller, L H, Rosengren, A, Svensson, P J, Nagel, D, Crespo, C J, Brenner, H, Albertorio-Diaz, J R, Atkins, R, Brunner, E J, Shipley, M, Njølstad, I, Lawlor, D A, van der Schouw, Y T, Selmer, R M, Trevisan, M, Verschuren, W M M, Greenland, P, Wassertheil-Smoller, S, Lowe, G D O, Wood, A M, Butterworth, A S, Thompson, S G, Danesh, J, di Angelantonio, E & Meade, T 2019, ' Cardiovascular Risk Factors Associated with Venous Thromboembolism ', JAMA cardiology, vol. 4, no. 2, pp. 163-173 . https://doi.org/10.1001/jamacardio.2018.4537Test JAMA Cardiology, 4(2), 163-173. American Medical Association JAMA cardiology, 4(2), 163-173. American Medical Association JAMA Cardiology, 4(2), 163. American Medical Association JAMA Cardiology Emerging Risk Factors Collaboration 2019, ' Cardiovascular Risk Factors Associated With Venous Thromboembolism ', JAMA Cardiology, vol. 4, no. 2, pp. 163-173 . https://doi.org/10.1001/jamacardio.2018.4537Test |
| بيانات النشر: | Amer Medical Assoc, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Outcome Assessment, ALCOHOL-CONSUMPTION, Coronary Disease, 030204 cardiovascular system & hematology, Body Mass Index, 0302 clinical medicine, Risk Factors, Outcome Assessment, Health Care, Cardiac and Cardiovascular Systems, 030212 general & internal medicine, Prospective Studies, DEEP-VEIN THROMBOSIS, Prospective cohort study, Original Investigation, Venous Thrombosis, education.field_of_study, Kardiologi, Hazard ratio, INDIVIDUAL-PARTICIPANT DATA, Venous Thromboembolism, Middle Aged, Biobank, 3. Good health, Pulmonary embolism, ddc, Cardiovascular Diseases, OBESITY, Female, SMOKING, Cardiology and Cardiovascular Medicine, Cohort study, Adult, medicine.medical_specialty, PULMONARY-EMBOLISM, Population, 03 medical and health sciences, Internal medicine, medicine, Journal Article, Diabetes Mellitus, Online First, Life Science, Humans, CORONARY-HEART-DISEASE, ddc:610, Obesity, Pulmonary Embolism, Smoking, United Kingdom, Risk factor, education, METAANALYSIS, VLAG, Global Nutrition, Wereldvoeding, business.industry, Research, DIABETES-MELLITUS, medicine.disease, Health Care, LIPOPROTEIN, business, Body mass index |
| الوصف: | Key Points Question To what extent are established cardiovascular risk factors associated with risk of venous thromboembolism (VTE)? Findings In this analysis of individual participant data from the Emerging Risk Factors Collaboration and the UK Biobank including 1.1 million participants, among a panel of several established cardiovascular risk factors, older age, smoking, and greater adiposity were consistently associated with higher VTE risk. Meaning There is overlap in at least some of the major population determinants of important venous and arterial thrombotic diseases. This analysis of data from the Emerging Risk Factors Collaboration and the UK Biobank estimates the associations of major cardiovascular risk factors with venous thromboembolism. Importance It is uncertain to what extent established cardiovascular risk factors are associated with venous thromboembolism (VTE). Objective To estimate the associations of major cardiovascular risk factors with VTE, ie, deep vein thrombosis and pulmonary embolism. Design, Setting, and Participants This study included individual participant data mostly from essentially population-based cohort studies from the Emerging Risk Factors Collaboration (ERFC; 731 728 participants; 75 cohorts; years of baseline surveys, February 1960 to June 2008; latest date of follow-up, December 2015) and the UK Biobank (421 537 participants; years of baseline surveys, March 2006 to September 2010; latest date of follow-up, February 2016). Participants without cardiovascular disease at baseline were included. Data were analyzed from June 2017 to September 2018. Exposures A panel of several established cardiovascular risk factors. Main Outcomes and Measures Hazard ratios (HRs) per 1-SD higher usual risk factor levels (or presence/absence). Incident fatal outcomes in ERFC (VTE, 1041; coronary heart disease [CHD], 25 131) and incident fatal/nonfatal outcomes in UK Biobank (VTE, 2321; CHD, 3385). Hazard ratios were adjusted for age, sex, smoking status, diabetes, and body mass index (BMI). Results Of the 731 728 participants from the ERFC, 403 396 (55.1%) were female, and the mean (SD) age at the time of the survey was 51.9 (9.0) years; of the 421 537 participants from the UK Biobank, 233 699 (55.4%) were female, and the mean (SD) age at the time of the survey was 56.4 (8.1) years. Risk factors for VTE included older age (ERFC: HR per decade, 2.67; 95% CI, 2.45-2.91; UK Biobank: HR, 1.81; 95% CI, 1.71-1.92), current smoking (ERFC: HR, 1.38; 95% CI, 1.20-1.58; UK Biobank: HR, 1.23; 95% CI, 1.08-1.40), and BMI (ERFC: HR per 1-SD higher BMI, 1.43; 95% CI, 1.35-1.50; UK Biobank: HR, 1.37; 95% CI, 1.32-1.41). For these factors, there were similar HRs for pulmonary embolism and deep vein thrombosis in UK Biobank (except adiposity was more strongly associated with pulmonary embolism) and similar HRs for unprovoked vs provoked VTE. Apart from adiposity, these risk factors were less strongly associated with VTE than CHD. There were inconsistent associations of VTEs with diabetes and blood pressure across ERFC and UK Biobank, and there was limited ability to study lipid and inflammation markers. Conclusions and Relevance Older age, smoking, and adiposity were consistently associated with higher VTE risk. |
| وصف الملف: | application/pdf; application/octet-stream; text; image/pdf |
| اللغة: | English |
| تدمد: | 2380-6583 2380-6591 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8b85df711995d7f44bedf157eaf325Test https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=55322Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7b8b85df711995d7f44bedf157eaf325 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23806583 23806591 |
|---|