The impact of biological sex on diseases of the urinary tract
| العنوان: | The impact of biological sex on diseases of the urinary tract |
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| المؤلفون: | Léa Deltourbe, Livia Lacerda Mariano, Teri N. Hreha, David A. Hunstad, Molly A. Ingersoll |
| المساهمون: | Institut Cochin (IC UM3 (UMR 8104 / U1016)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Inflammation et immunité des muqueuses - Mucosal Inflammation and Immunity, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Washington University School of Medicine [Saint Louis, MO], We also gratefully acknowledge our finding sources. L.D. and L.L.M. have received support from the Labex Milieu Intérieur (ANR-10-LABX-69-01). L.L.M. was part of the Pasteur-Paris University (PPU) International PhD Program, which received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 665807. Work cited herein is supported by the US National Institutes of Health (D.A.H.: R01-DK111541, R01-DK126697, R01-AI158418) and the Agence Nationale de la Recherche (M.A.I.: ANR-19-CE15-0015-01, ANR-21-CE15-0006-02)., ANR-10-LABX-0069,MILIEU INTERIEUR,GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE(2010), ANR-19-CE15-0015,BladderMacs,Fonction, origine, et homéostasie des macrophages résidents de la vessie(2019), ANR-21-CE15-0006,ExPECtation,Colonisation des tissus et resevoirs infectieux des ExPEC induits par CNF1, nouvelle voie thérapeutique(2021), European Project: 665807,H2020,H2020-MSCA-COFUND-2014,PASTEURDOC(2015), Vougny, Marie-Christine, Laboratoires d'excellence - GENETIC & ENVIRONMENTAL CONTROL OF IMMUNE PHENOTYPE VARIANCE: ESTABLISHING A PATH TOWARDS PERSONALIZED MEDICINE - - MILIEU INTERIEUR2010 - ANR-10-LABX-0069 - LABX - VALID, Fonction, origine, et homéostasie des macrophages résidents de la vessie - - BladderMacs2019 - ANR-19-CE15-0015 - AAPG2019 - VALID, Colonisation des tissus et resevoirs infectieux des ExPEC induits par CNF1, nouvelle voie thérapeutique - - ExPECtation2021 - ANR-21-CE15-0006 - AAPG2021 - VALID, Institut Pasteur International Docotal Program - PASTEURDOC - - H20202015-10-01 - 2020-10-01 - 665807 - VALID |
| المصدر: | Mucosal Immunology Mucosal Immunology, 2022, 15 (5), pp.857-866. ⟨10.1038/s41385-022-00549-0⟩ |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, Sex Characteristics, MESH: Humans, [SDV.IMM] Life Sciences [q-bio]/Immunology, Immunology, MESH: Urinary Tract Infections, MESH: Male, MESH: Urinary Bladder Neoplasms, Urinary Bladder Neoplasms, MESH: Urinary Tract, Urinary Tract Infections, [SDV.IMM]Life Sciences [q-bio]/Immunology, Immunology and Allergy, Humans, Female, Gonadal Steroid Hormones, Urinary Tract, MESH: Female, MESH: Gonadal Steroid Hormones, MESH: Sex Characteristics |
| الوصف: | International audience; Biological sex, being female or male, broadly influences diverse immune phenotypes, including immune responses to diseases at mucosal surfaces. Sex hormones, sex chromosomes, sexual dimorphism, and gender differences all contribute to how an organism will respond to diseases of the urinary tract, such as bladder infection or cancer. Although the incidence of urinary tract infection is strongly sex biased, rates of infection change over a lifetime in women and men, suggesting that accompanying changes in the levels of sex hormones may play a role in the response to infection. Bladder cancer is also sex biased in that 75% of newly diagnosed patients are men. Bladder cancer development is shaped by contributions from both sex hormones and sex chromosomes, demonstrating that the influence of sex on disease can be complex. With a better understanding of how sex influences disease and immunity, we can envision sex-specific therapies to better treat diseases of the urinary tract and potentially diseases of other mucosal tissues. |
| تدمد: | 1935-3456 1933-0219 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2e7395c93bbd619ae91c01f55a3c66Test https://pubmed.ncbi.nlm.nih.gov/35869147Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....7b2e7395c93bbd619ae91c01f55a3c66 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19353456 19330219 |
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