Are all RAS mutations the same? Coexisting KRAS and NRAS mutations in a caecal adenocarcinoma and contiguous tubulovillous adenoma
| العنوان: | Are all RAS mutations the same? Coexisting KRAS and NRAS mutations in a caecal adenocarcinoma and contiguous tubulovillous adenoma |
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| المؤلفون: | Nina Vagaja, M A Thomas, Jacqueline M. Bentel, Jeremy Parry, Dugald McCallum |
| المصدر: | Journal of Clinical Pathology. 68:657-660 |
| بيانات النشر: | BMJ, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Neuroblastoma RAS viral oncogene homolog, medicine.medical_specialty, Colorectal cancer, Biopsy, DNA Mutational Analysis, Viral Oncogene, Cecal Neoplasms, Adenocarcinoma, Biology, medicine.disease_cause, GTP Phosphohydrolases, Pathology and Forensic Medicine, Proto-Oncogene Proteins p21(ras), Proto-Oncogene Proteins, Molecular genetics, Tubulovillous adenoma, Adenoma, Villous, Biomarkers, Tumor, medicine, Humans, Genetic Predisposition to Disease, neoplasms, Colectomy, Genetics, Molecular pathology, Membrane Proteins, General Medicine, medicine.disease, Immunohistochemistry, digestive system diseases, Mutation, ras Proteins, Cancer research, KRAS, Neoplasm Grading |
| الوصف: | Mutations of the human Kirsten rat sarcoma viral oncogene homologue (KRAS) and the highly homologous human neuroblastoma RAS viral oncogene homologue (NRAS) are associated with resistance to antiepidermal growth factor receptor therapies in patients with colorectal cancer. In this report, we describe a caecal adenocarcinoma that contains both KRAS c.35G>T (G12V) and NRAS c.34G>A (G12S) mutations. The adenocarcinoma arises from a contiguous high-grade tubulovillous adenoma, which also carries the identical KRAS and NRAS mutations, supporting their common origin. While KRAS mutations are common in colorectal cancers, NRAS mutations are relatively rare and the coexistence of multiple RAS mutations is not documented, presumably reflecting similar functions of wild-type and mutant forms of RAS. Recent experimental evidence has suggested that KRAS and NRAS may in fact mediate distinct biological processes in the colon, and this unusual case potentially illustrates the hypothesis clinically. Characterisation of the diverse and divergent functions of RAS family members and mutant forms of RAS in the colon form important considerations for the development of RAS-targeting therapeutics. |
| تدمد: | 1472-4146 0021-9746 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2b809d32e63adbfbcb0b2662570fe6Test https://doi.org/10.1136/jclinpath-2015-202969Test |
| رقم الانضمام: | edsair.doi.dedup.....7b2b809d32e63adbfbcb0b2662570fe6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14724146 00219746 |
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