Risk of early mortality and cardiovascular disease in type 1 diabetes: a comparison with type 2 diabetes, a nationwide study
| العنوان: | Risk of early mortality and cardiovascular disease in type 1 diabetes: a comparison with type 2 diabetes, a nationwide study |
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| المؤلفون: | Jiyeon Ahn, Bongsung Kim, Seung Eun Lee, Kyungdo Han, Sang-Man Jin, Jae Hyeon Kim, Ji Eun Jun, You-Bin Lee, Gyuri Kim |
| المصدر: | Cardiovascular Diabetology Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-17 (2019) |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, Time Factors, Databases, Factual, Endocrinology, Diabetes and Metabolism, Myocardial Infarction, Type 1 diabetes mellitus, Heart failure, Disease, Type 2 diabetes, Risk Assessment, Risk Factors, Cause of Death, Internal medicine, Diabetes mellitus, Atrial Fibrillation, Republic of Korea, Epidemiology, medicine, Humans, Longitudinal Studies, Myocardial infarction, Original Investigation, Aged, Retrospective Studies, Type 1 diabetes, Proportional hazards model, business.industry, Incidence, Hazard ratio, Middle Aged, Prognosis, medicine.disease, Morality, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, lcsh:RC666-701, Cardiovascular Diseases, Female, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Background Both type 1 and type 2 diabetes are well-established risk factors for cardiovascular disease and early mortality. However, few studies have directly compared the hazards of cardiovascular outcomes and premature death among people with type 1 diabetes to those among people with type 2 diabetes and subjects without diabetes. Furthermore, information about the hazard of cardiovascular disease and early mortality among Asians with type 1 diabetes is sparse, although the clinical and epidemiological characteristics of Asians with type 1 diabetes are unlike those of Europeans. We estimated the hazard of myocardial infarction (MI), hospitalization for heart failure (HF), atrial fibrillation (AF), and mortality during follow-up in Korean adults with type 1 diabetes compared with those without diabetes and those with type 2 diabetes. Methods We used Korean National Health Insurance Service datasets of preventive health check-ups from 2009 to 2016 in this retrospective longitudinal study. The hazard ratios of MI, HF, AF, and mortality during follow-up were analyzed using the Cox regression analyses according to the presence and type of diabetes in ≥ 20-year-old individuals without baseline cardiovascular disease (N = 20,423,051). The presence and type of diabetes was determined based on the presence of type 1 or type 2 diabetes at baseline. Results During more than 93,300,000 person-years of follow-up, there were 116,649 MIs, 135,532 AF cases, 125,997 hospitalizations for HF, and 344,516 deaths. The fully-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for incident MI, hospitalized HF, AF, and all-cause death within the mean follow-up of 4.6 years were higher in the type 1 diabetes group than the type 2 diabetes [HR (95% CI) 1.679 (1.490–1.893) for MI; 2.105 (1.901–2.330) for HF; 1.608 (1.411–1.833) for AF; 1.884 (1.762–2.013) for death] and non-diabetes groups [HR (95% CI) 2.411 (2.138–2.718) for MI; 3.024 (2.730–3.350) for HF; 1.748 (1.534–1.993) for AF; 2.874 (2.689–3.073) for death]. Conclusions In Korea, the presence of diabetes was associated with a higher hazard of cardiovascular disease and all-cause death. Specifically, people with type 1 diabetes had a higher hazard of cardiovascular disease and all-cause mortality compared to people with type 2 diabetes. |
| تدمد: | 1475-2840 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7994a8d0cf11d2d263cb3617566af34dTest https://doi.org/10.1186/s12933-019-0953-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7994a8d0cf11d2d263cb3617566af34d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752840 |
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