In Vivo Choroidal Vascular Lesions in Diabetes on Swept-Source Optical Coherence Tomography
| العنوان: | In Vivo Choroidal Vascular Lesions in Diabetes on Swept-Source Optical Coherence Tomography |
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| المؤلفون: | Rima Ghashut, Masahiro Fujimoto, Nagahisa Yoshimura, Rina Yoza, Shin Yoshitake, Akihito Uji, Kiyoshi Suzuma, Tomoaki Murakami, Yoko Dodo |
| المصدر: | PLoS ONE PLoS ONE, Vol 11, Iss 8, p e0160317 (2016) |
| بيانات النشر: | Public Library of Science, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Pigments, Male, Visual acuity, genetic structures, lcsh:Medicine, Pathogenesis, Pathology and Laboratory Medicine, Severity of Illness Index, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Medicine and Health Sciences, lcsh:Science, Multidisciplinary, medicine.diagnostic_test, Diabetic retinopathy, Middle Aged, Vascular narrowing, medicine.anatomical_structure, Physical Sciences, Hypertension, Retinal Disorders, Female, medicine.symptom, Anatomy, Tomography, Optical Coherence, Research Article, Adult, medicine.medical_specialty, Histology, Endocrine Disorders, Ocular Anatomy, Materials Science, Retina, 03 medical and health sciences, Signs and Symptoms, Imaging, Three-Dimensional, Optical coherence tomography, In vivo, Ocular System, Diagnostic Medicine, Ophthalmology, Diabetes mellitus, medicine, Diabetes Mellitus, Humans, Retinopathy, Materials by Attribute, Aged, Retrospective Studies, Diabetic Retinopathy, business.industry, Choroid, lcsh:R, Biology and Life Sciences, Retinal Vessels, Retinal, medicine.disease, eye diseases, Surgery, 030104 developmental biology, Diabetes Mellitus, Type 1, chemistry, Diabetes Mellitus, Type 2, Metabolic Disorders, Case-Control Studies, 030221 ophthalmology & optometry, Lesions, Eyes, lcsh:Q, sense organs, Bruch Membrane, business, Head |
| الوصف: | Diabetes induces microvascular diseases including diabetic retinopathy and choroidopathy which reciprocally promote the pathogenesis, although optical coherence tomography images of diabetic choroidopathy remains to be documented. Here we evaluated the qualitative characteristics of choroidal vascular lesions in patients with diabetes and their association with diabetic retinopathy on swept-source optical coherence tomography (SS-OCT) images. We retrospectively reviewed 110 consecutive eyes of 110 patients with diabetes and 35 eyes of 35 healthy subjects for whom SS-OCT images (6x6-mm scans centered on the fovea) of sufficient quality were acquired. The curve of chorioretinal sections was flattened using Bruch's membrane as a reference surface, followed by generation of en-face images. We characterized choroidal vascular lesions and evaluated their association with the logarithm of the minimum angle of resolution visual acuity (logMAR VA), retinal and choroidal thicknesses, and diabetic retinopathy severity. En-face SS-OCT images showed unvisualized vessels in Sattler's layer in 33 eyes (30.0%). Focal narrowing was seen in choroidal vessels in Haller's layer in 56 eyes (50.9%). The choroidal vessels ended in the superficial or middle portion of Haller's layer, referred to as vascular stumps, in 20 eyes (18.2%). Diabetic eyes had these findings more frequently than nondiabetic eyes. The subfoveal choroid was thicker in eyes with focal vascular narrowing and vascular stumps than in eyes without such lesions. Vascular stumps in Haller's layer were significantly related to diabetic retinopathy severity, logMAR VA, and central retinal and choroidal thicknesses. These novel findings on SS-OCT images would promote the better understanding of complicated pathogenesis in diabetic retinopathy and choroidopathy. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797367363d596998df1335e3d761a044Test http://europepmc.org/articles/PMC4968792Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....797367363d596998df1335e3d761a044 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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