First year on commercial hybrid closed‐loop system—experience on 111 children and adolescents with type 1 diabetes
| العنوان: | First year on commercial hybrid closed‐loop system—experience on 111 children and adolescents with type 1 diabetes |
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| المؤلفون: | Elina Hakonen, Anna-Kaisa Tuomaala, Päivi J. Miettinen, Tero Varimo, Matti Hero, Mari-Anne Pulkkinen |
| المساهمون: | HUS Children and Adolescents, Children's Hospital, University of Helsinki, Helsinki University Hospital Area, Raivio Group, Clinicum, Centre of Excellence in Stem Cell Metabolism, Timo Pyry Juhani Otonkoski / Principal Investigator, Research Programs Unit |
| المصدر: | Pediatric Diabetes. 22:909-915 |
| بيانات النشر: | Hindawi Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Research design, medicine.medical_specialty, Adolescent, type 1 diabetes, Endocrinology, Diabetes and Metabolism, Coefficient of variation, 030209 endocrinology & metabolism, MICROVASCULAR COMPLICATIONS, THERAPY, 03 medical and health sciences, Insulin Infusion Systems, 0302 clinical medicine, 3123 Gynaecology and paediatrics, Internal medicine, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Insulin, hybrid closed-loop system, 030212 general & internal medicine, Child, Retrospective Studies, Glycemic, Type 1 diabetes, business.industry, Infant, Treatment method, Retrospective cohort study, University hospital, medicine.disease, 3. Good health, LIFE, Diabetes Mellitus, Type 1, Child, Preschool, 3121 General medicine, internal medicine and other clinical medicine, Pediatrics, Perinatology and Child Health, glycemic control, Female, business, Closed loop |
| الوصف: | Objective The hybrid close-loop system (HCL) is a rapidly emerging treatment method for type 1 diabetes (T1D), but the long-term effectiveness of the system remains unclear. This study investigates the influence of the HCL on glycemic control in children and adolescents with T1D in a real-life setting during the first year on HCL. Research design and methods This retrospective study included all the patients (n = 111) aged 3 to 16 years with T1D who initiated the HCL system between 1st of December 2018 and 1st of December 2019 in the Helsinki University Hospital. Time in range (TIR), HbA1c, mean sensor glucose (SG) value, time below range (TBR), and SG coefficient of variance (CV) were measured at 0, 1, 3, 6, and 12 month. The changes over time were analyzed with a repeated mixed model adjusted with baseline glycemic control. Results After the initiation of HCL, all measures of glycemic control, except HbA1c, improved and the effect lasted throughout the study period. Between 0 and 12 month, TIR increased (beta = -2.5 [95%CI: -3.6 - (-1.3)], p < 0.001), whereas mean SG values (beta = -0.7 [95%CI: -0.9 - (-0.4)]), TBR (beta = -2.5 [95%CI: -3.6 - (-1.3)]), and SG CV (beta = -4.5 [95%CI: -6.3 - [-2.8]) decreased significantly (p < 0.001). Importantly, the changes occurred regardless of the age of the patient. Conclusions Measurements of glycemic control, except HbA1c, improved significantly after the initiation of the HCL system and the favorable effect lasted throughout the follow-up. These results support the view that HCL is an efficacious treatment modality for children and adolescents with T1D of all ages. |
| تدمد: | 1399-5448 1399-543X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796f44f4506aa7a3fee7e671f19a8e9aTest https://doi.org/10.1111/pedi.13235Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....796f44f4506aa7a3fee7e671f19a8e9a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13995448 1399543X |
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