Low-dose CT measurements of airway dimensions and emphysema associated with airflow limitation in heavy smokers: a cross sectional study
| العنوان: | Low-dose CT measurements of airway dimensions and emphysema associated with airflow limitation in heavy smokers: a cross sectional study |
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| المؤلفون: | Peter M. A. van Ooijen, Akkelies E. Dijkstra, Firdaus A. A. Mohamed Hoesein, Matthijs Oudkerk, Bram van Ginneken, Dirkje S. Postma, Judith M. Vonk, Harry J.M. Groen, Nick H. T. ten Hacken, Pieter Zanen, Michael Schmidt |
| المساهمون: | Groningen Research Institute of Pharmacy, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Life Course Epidemiology (LCE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Lifestyle Medicine (LM), Groningen Research Institute for Asthma and COPD (GRIAC) |
| المصدر: | Respiratory Research, 14:11. BioMed Central Ltd. Respiratory Research, 14, 1-9 Respiratory Research, Vol 14, Iss 1, p 11 (2013) Respiratory Research Respiratory Research; Vol 14 Respiratory Research, 14, pp. 1-9 |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, BIOMARKER, Respiratory System, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, ATTENUATION, Forced Expiratory Volume, Respiratory symptoms, Quantitative computed tomography, Lung, COPD, education.field_of_study, HEALTH-STATUS, Anatomy, Cross-Sectional, medicine.diagnostic_test, Smoking, BODE-INDEX, Middle Aged, respiratory system, METRICS, Respiratory Function Tests, 3. Good health, medicine.anatomical_structure, Pulmonary Emphysema, Data Interpretation, Statistical, Radiology, Lung Volume Measurements, Poverty-related infectious diseases Aetiology, screening and detection [N4i 3], Pulmonary and Respiratory Medicine, Spirometry, BODE index, medicine.medical_specialty, Population, Airway dimensions, OBSTRUCTIVE PULMONARY-DISEASE, 03 medical and health sciences, Airflow limitation, medicine, WALL THICKNESS, Humans, education, lcsh:RC705-779, Emphysema, Low-dose CT, business.industry, Research, QUANTITATIVE COMPUTED-TOMOGRAPHY, lcsh:Diseases of the respiratory system, medicine.disease, respiratory tract diseases, 030228 respiratory system, Linear Models, Tomography, X-Ray Computed, Airway, business, Lung cancer screening |
| الوصف: | Contains fulltext : 118757.pdf (Publisher’s version ) (Open Access) ABSTRACT: BACKGROUND: Increased airway wall thickness (AWT) and parenchymal lung destruction both contribute to airflow limitation. Advances in computed tomography (CT) post-processing imaging allow to quantify these features. The aim of this Dutch population study is to assess the relationships between AWT, lung function, emphysema and respiratory symptoms. METHODS: AWT and emphysema were assessed by low-dose CT in 500 male heavy smokers, randomly selected from a lung cancer screening population. AWT was measured in each lung lobe in cross-sectionally reformatted images with an automated imaging program at locations with an internal diameter of 3.5 mm, and validated in smaller cohorts of patients. The 15th percentile method (Perc15) was used to assess the severity of emphysema. Information about respiratory symptoms and smoking behavior was collected by questionnaires and lung function by spirometry. RESULTS: Median AWT in airways with an internal diameter of 3.5 mm (AWT3.5) was 0.57 (0.44 - 0.74) mm. Median AWT in subjects without symptoms was 0.52 (0.41-0.66) and in those with dyspnea and/or wheezing 0.65 (0.52-0.81) mm (p |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1465-993X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c521ebcd689d63cdf6313a9596c5efTest https://research.rug.nl/en/publications/4a8f8ec0-a80d-4abf-9d38-f9a111ca836cTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....78c521ebcd689d63cdf6313a9596c5ef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1465993X |
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