Clinicopathological and prognostic implications of ALK rearrangement in patients with completely surgically resected lung adenocarcinoma
| العنوان: | Clinicopathological and prognostic implications of |
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| المؤلفون: | Guoshu Bi, Valeria Besskaya, Huan Zhang, Jiaqi Liang, Guangyao Shan, Songtao Xu, Zhencong Chen, Lin Wang, Yuansheng Zheng, Cheng Zhan, Weigang Guo, Benjie Cai |
| المصدر: | Thoracic Cancer, Vol 12, Iss 22, Pp 3011-3018 (2021) Thoracic Cancer |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, ALK inhibitors, Pulmonary and Respiratory Medicine, Oncology, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, Adenocarcinoma of Lung, Pulmonary Surgical Procedures, Targeted therapy, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Anaplastic Lymphoma Kinase, Radical surgery, Stage (cooking), Pathological, RC254-282, Aged, Retrospective Studies, Gene Rearrangement, Univariate analysis, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Retrospective cohort study, Original Articles, General Medicine, Middle Aged, lung adenocarcinoma, medicine.disease, Primary tumor, clinical feature, Survival Rate, anaplastic lymphoma kinase (ALK), Case-Control Studies, Adenocarcinoma, Female, Original Article, prognosis, business |
| الوصف: | Background The prognostic significance of ALK rearrangement is still contradictory. Here, we aimed to investigate the clinical characteristics and outcomes of lung adenocarcinoma patients with ALK rearrangement, and analyze whether these patients benefited from targeted therapy. Methods This was a retrospective cohort study of 80 ALK‐rearranged lung adenocarcinoma patients who had undergone radical surgery and another 3031 ALK mutation‐negative patients were retrospectively reviewed for inclusion in this case‐controlled analyses. Overall survival (OS) was evaluated using the Kaplan‐–Meier method. Univariate analysis (UVA) and multivariate analysis (MVA) by the Cox proportional hazards regression identified risk factors that predicted OS. Results Compared to ALK‐negative patients, the ALK rearranged patients were younger, with more non‐smokers, more females, a larger primary tumor was demonstrated, and were a higher pathological stage. In particular, the risk of lymph node metastasis was higher. For patients with surgically‐resected tumors, the prognosis was better for ALK rearranged patients (HR = 0.503; 95% CI: 0.259–0.974, p = 0.041). In addition, for stage II–III patients, targeted therapy was an independent prognostic factor of better OS (HR = 0.159; 95% CI: 0.032–0.801, p = 0.026). Conclusions ALK rearranged lung adenocarcinoma patients who have undergone radical surgery have distinct clinical features. Patients with ALK rearrangement may have a favorable prognosis, and stage II–III patients may benefit from targeted treatment. The article compared 80 ALK+ and 3031 ALK‐ lung adenocarcinoma patients after surgery, explored the clinicopathological characteristics and prognostic features of ALK+ lung adenocarcinoma patients, and analyzed the impact of targeted drugs on the survival of ALK+ lung adenocarcinoma patients after surgery. |
| تدمد: | 1759-7714 1759-7706 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78722f929edd2f16157d56c3e4829be9Test https://doi.org/10.1111/1759-7714.14170Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....78722f929edd2f16157d56c3e4829be9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17597714 17597706 |
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