Identification of an individualized RNA binding protein‐based prognostic signature for diffuse large B‐cell lymphoma
| العنوان: | Identification of an individualized RNA binding protein‐based prognostic signature for diffuse large B‐cell lymphoma |
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| المؤلفون: | Yongzhi Xie, Haiqing He, Ximei Luo, Yizi He, Tao Pan |
| المصدر: | Cancer Medicine, Vol 10, Iss 8, Pp 2703-2713 (2021) Cancer Medicine |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Cancer Research, Notch signaling pathway, RNA-binding protein, Kaplan-Meier Estimate, Biology, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, Biomarkers, Tumor, medicine, Humans, prognostic model, Radiology, Nuclear Medicine and imaging, Clinical significance, Precision Medicine, Gene, B cell receptor signaling pathway, Original Research, Aged, Proportional Hazards Models, diffuse large B‐cell lymphoma, Clinical Cancer Research, RNA-Binding Proteins, Reproducibility of Results, Myeloid leukemia, RNA‐binding proteins, Middle Aged, medicine.disease, GEO, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Lymphoma, Gene Expression Regulation, Neoplastic, Nomograms, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, Female, Lymphoma, Large B-Cell, Diffuse, prognosis, Diffuse large B-cell lymphoma |
| الوصف: | RNA binding proteins (RBPs) are increasingly appreciated as being essential for normal hematopoiesis and have a critical role in the progression of hematological malignancies. However, their functional consequences and clinical significance in diffuse large B‐cell lymphoma (DLBCL) remain unknown. Here, we conducted a systematic analysis to identify RBP‐related genes affecting DLBCL prognosis based on the Gene Expression Omnibus database. By univariate and multivariate Cox proportional hazards regression (CPHR) methods, six RBPs‐related genes (CMSS1, MAEL, THOC5, PSIP1, SNIP1, and ZCCHC7) were identified closely related to the overall survival (OS) of DLBCL patients. The RBPs signature could efficiently distinguished low‐risk from high‐risk patients and could serve as an independent and reliable factor for predicting OS. Moreover, Gene Set Enrichment Analysis revealed 17 significantly enriched pathways between high‐ versus low‐risk group, including the regulation of autophagy, chronic myeloid leukemia, NOTCH signaling pathway, and B cell receptor signaling pathway. Then we developed an RBP‐based nomogram combining other clinical risk factors. The receiver operating characteristic curve analysis demonstrated high prognostic predictive efficiency of this model with the area under the curve values were 0.820 and 0.780, respectively, in the primary set and entire set. In summary, our RBP‐based model could be a novel prognostic predictor and had the potential for developing treatment targets for DLBCL. We found that six RNA binding proteins are significantly related to the overall survival of diffuse large B‐cell lymphoma (DLBCL) patients, which could potentially be served as prognostic biomarkers. Gene Set Enrichment Analysis provided insight into the underlying mechanisms in the occurrence and development of DLBCL, which laid the foundation for further basic studies. |
| اللغة: | English |
| تدمد: | 2045-7634 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ff2619896167a6f36250217b368154Test https://doaj.org/article/a20196e96da142089e827680abebdf51Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....77ff2619896167a6f36250217b368154 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20457634 |
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