Elevated urinary N-acetyl-β-D-glucosaminidase is associated with high glycoalbumin-to-hemoglobin A1c ratio in type 1 diabetes patients with early diabetic kidney disease
| العنوان: | Elevated urinary N-acetyl-β-D-glucosaminidase is associated with high glycoalbumin-to-hemoglobin A1c ratio in type 1 diabetes patients with early diabetic kidney disease |
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| المؤلفون: | Min Young Lee, So-Young Park, Yong Ho Lee, Byung Wan Lee, Sang-Man Jin, Jae Hyeon Kim, Namki Hong |
| المصدر: | Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018) Scientific Reports |
| بيانات النشر: | Nature Portfolio, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Glycation End Products, Advanced, Male, medicine.medical_specialty, endocrine system diseases, Science, Renal function, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Article, Excretion, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Internal medicine, Diabetes mellitus, Acetylglucosaminidase, medicine, Albuminuria, Humans, Diabetic Nephropathies, Glycated Serum Albumin, Serum Albumin, Aged, Glycated Hemoglobin, Creatinine, Type 1 diabetes, Multidisciplinary, business.industry, Middle Aged, medicine.disease, Endocrinology, Postprandial, Diabetes Mellitus, Type 1, chemistry, Hyperglycemia, Medicine, Female, medicine.symptom, business, Body mass index, Biomarkers, Glomerular Filtration Rate |
| الوصف: | Urinary N-acetyl-β-D-glucosaminidase (uNAG) predicted the progression of diabetic kidney disease (DKD) prior to development of albuminuria in diabetes patients. We sought whether uNAG level is associated with glycoalbumin-to-hemoglobin A1c ratio (G/A ratio), a marker of postprandial hyperglycemia and glycemic excursion, independent of albuminuria and kidney function. The association between uNAG excretion and G/A ratio was assessed in 204 consecutive subjects with type 1 diabetes (T1D) (mean age 43.9 years; 49.0% men). uNAG excretion level increased along with older age, hyperglycemia, and degree of albuminuria, but was not correlated with body mass index or estimated glomerular filtration rate (eGFR). Elevated uNAG showed robust association with higher G/A ratio (adjusted β = 0.103, P = 0.020) after adjustment for age, sex, body mass index, duration of diabetes, uACR, angiotensin blockers use, fasting plasma glucose, and hemoglobin level. uNAG showed better discriminatory performance for individuals with high G/A ratio than albuminuria (AUC 0.613 vs. 0.518, P = 0.038). Measurement of uNAG improved AUC for high G/A ratio from 0.699 to 0.748 (P = 0.043) when added to conventional risk factors (cutoff 5.24 U/g creatinine; sensitivity 62.5% and specificity 58.0%). In conclusion, Elevated uNAG was found to be associated with high G/A ratio in patients with T1D with early stage DKD, independent of age and albuminuria. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779ae45ed5210872dcff54c658ce4a3aTest https://doaj.org/article/002499d600e44a1d8454459bc22ba5f3Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....779ae45ed5210872dcff54c658ce4a3a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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