Pancreatic Cancer Screening in a Prospective Cohort of High-Risk Patients: A Comprehensive Strategy of Imaging and Genetics
| العنوان: | Pancreatic Cancer Screening in a Prospective Cohort of High-Risk Patients: A Comprehensive Strategy of Imaging and Genetics |
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| المؤلفون: | Harold Frucht, Wendy K. Chung, Peter D. Stevens, Caroline Hwang, Elizabeth C. Verna, Martin A. Prince, Heidrun Rotterdam, Carolyn D. Sy, John A. Chabot, Stavros N. Stavropoulos, Robert L. Fine |
| المصدر: | Clinical Cancer Research. 16:5028-5037 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, Endoscopic ultrasound, Cancer Research, Pancreatic disease, medicine.medical_treatment, Genes, BRCA2, Genes, BRCA1, Pancreatic Intraepithelial Neoplasia, Cohort Studies, Risk Factors, Pancreatic cancer, Humans, Medicine, Genetic Predisposition to Disease, Prospective Studies, Prospective cohort study, Early Detection of Cancer, Adaptor Proteins, Signal Transducing, Aged, Genetics, medicine.diagnostic_test, business.industry, Genes, p16, Nuclear Proteins, Cancer, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Pancreatic Neoplasms, MutS Homolog 2 Protein, medicine.anatomical_structure, Oncology, Pancreatectomy, Female, MutL Protein Homolog 1, business, Pancreas |
| الوصف: | Purpose: Pancreatic cancer is a virtually uniformly fatal disease. We aimed to determine if screening to identify curable neoplasms is effective when offered to patients at high risk. Experimental Design: Patients at high risk of pancreatic cancer were prospectively enrolled into a screening program. Endoscopic ultrasound (EUS), magnetic resonance imaging (MRI), and genetic testing were offered by a multidisciplinary team according to each patient's risk. Results: Fifty-one patients in 43 families were enrolled, with mean age of 52 years, 35% of whom were male. Of these patients, 31 underwent EUS and 33 MRI. EUS revealed two patients with pancreatic cancer (one resectable, one metastatic), five with intraductal papillary mucinous neoplasms (IPMN), seven with cysts, and six with parenchymal changes. Five had pancreatic surgery (one total pancreatectomy for pancreatic cancer, three distal and one central pancreatectomy for pancreatic intraepithelial neoplasia 2 and IPMN). A total of 24 (47%) had genetic testing (19 for BRCA1/2 mutations, 4 for CDKN2A, 1 for MLH1/MSH2) and 7 were positive for BRCA1/2 mutations. Four extrapancreatic neoplasms were found: two ovarian cancers on prophylactic total abdominal hysterectomy and bilateral salpingo-oophorectomy, one carcinoid, and one papillary thyroid carcinoma. Overall, 6 (12%) of the 51 patients had neoplastic lesions in the pancreas and 9 (18%) had neoplasms in any location. All were on the initial round of screening. All patients remain alive and without complications of screening. Conclusions: Pancreatic cancer screening for high-risk patients with a comprehensive strategy of imaging and genetics is effective and identifies curable neoplasms that can be resected. Ongoing study will better define who will benefit from screening and what screening strategy will be the most effective. Clin Cancer Res; 16(20); 5028–37. ©2010 AACR. |
| تدمد: | 1557-3265 1078-0432 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7785dd69f9ee0a789b8177a4d0d33713Test https://doi.org/10.1158/1078-0432.ccr-09-3209Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7785dd69f9ee0a789b8177a4d0d33713 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15573265 10780432 |
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