Antidepressant Drugs and Breastfeeding: A Review of the Literature
| العنوان: | Antidepressant Drugs and Breastfeeding: A Review of the Literature |
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| المؤلفون: | Alessandro Amaddeo, Riccardo Davanzo, Federico Minen, Angela De Cunto, Marco Copertino |
| المصدر: | Breastfeeding Medicine. 6:89-98 |
| بيانات النشر: | Mary Ann Liebert Inc, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Postpartum depression, Drug, medicine.medical_specialty, Pediatrics, Monoamine Oxidase Inhibitors, media_common.quotation_subject, Alternative medicine, MEDLINE, Breastfeeding, Biological Availability, Directive Counseling, Antidepressive Agents, Tricyclic, Depression, Postpartum, Pregnancy, Maternity and Midwifery, medicine, Humans, Lactation, Depression (differential diagnoses), media_common, Adrenergic Uptake Inhibitors, Milk, Human, business.industry, Health Policy, Infant, Newborn, Obstetrics and Gynecology, medicine.disease, Antidepressive Agents, Breast Feeding, Maternal Exposure, Family medicine, Lithium Compounds, Female, Drug Monitoring, Drugs in pregnancy, business, Selective Serotonin Reuptake Inhibitors |
| الوصف: | The use of antidepressants in breastfeeding mothers is controversial: Manufacters often routinely discourage breastfeeding for the nursing mother despite the well-known positive impact that breastfeeding carries on the health of the nursing infant and on his or her family and society. We conducted a systematic review of drugs commonly used in the treatment of postpartum depression. For every single drug two sets of data were provided: (1) selected pharmacokinetic characteristics such as half-life, milk-to-plasma ratio, protein binding, and oral bioavailability and (2) information about lactational risk, according to some authoritative sources of the literature: Drugs in Pregnancy and Lactation edited by Briggs et al. (Lippincott Williams, Philadelphia, 2008), Medications and Mothers' Milk by Hale (Hale Publishing, Amarillo, TX, 2010), and the LactMed database of TOXNET ( www.pubmed.gov ; accessed June 2010). Notwithstanding a certain variability of advice, we found that (1) knowledge of pharmacokinetic characteristics are scarcely useful to assess safety and (2) the majority of antidepressants are not usually contraindicated: (a) Selective serotinin reuptake inhibitors and nortryptiline have a better safety profile during lactation, (b) fluoxetine must be used carefully, (c) the tricyclic doxepine and the atypical nefazodone should better be avoided, and (d) lithium, usually considered as contraindicated, has been recently rehabilitated. |
| تدمد: | 1556-8342 1556-8253 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77379cc49953dd321ced679b03be4431Test https://doi.org/10.1089/bfm.2010.0019Test |
| رقم الانضمام: | edsair.doi.dedup.....77379cc49953dd321ced679b03be4431 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15568342 15568253 |
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