Predictors of positive bone cultures from CT‐guided bone biopsies performed for suspected osteomyelitis
| العنوان: | Predictors of positive bone cultures from CT‐guided bone biopsies performed for suspected osteomyelitis |
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| المؤلفون: | Harrison T. Lee, Ronnie Sebro |
| المصدر: | Journal of Medical Imaging and Radiation Oncology. 64:313-318 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Image-Guided Biopsy, Male, medicine.medical_specialty, Adolescent, Open wounds, Computed tomography, Logistic regression, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Biopsy, medicine, Humans, Radiology, Nuclear Medicine and imaging, Multivariable model, Aged, Retrospective Studies, Retrospective review, medicine.diagnostic_test, business.industry, Osteomyelitis, Area under the curve, Middle Aged, medicine.disease, Anti-Bacterial Agents, Oncology, 030220 oncology & carcinogenesis, Female, Tomography, X-Ray Computed, business, Biomarkers |
| الوصف: | Introduction Bone biopsies are often used to direct antibiotic choice in patients with suspected osteomyelitis. The aim of this study was to identify the best predictors of positive bone biopsy cultures. Methods A retrospective review of 845 patients who underwent computed tomography (CT)-guided non-spine bone biopsies at a tertiary academic healthcare institution. Thirty-seven patients (4.4%) had biopsies performed for suspected osteomyelitis. Laboratory markers, as well as imaging features, were measured. t-Tests and Fisher's exact tests were used to compare clinical and demographic variables between patients with positive bone cultures and patients with negative bone cultures. Multivariable logistic regression was used to identify the best predictors of bone culture positivity. Results All patients had negative blood cultures; however, only eight patients (21.6%) had positive bone cultures, with Staphyloccocus the most common organism. Multivariable logistic regression analysis showed that an open wound (OR = 14.00, 95% CI (1.74, 112.4), p = 0.013) and any fluid aspirated at the time of biopsy (OR = 10.50, 95% CI (1.21, 91.01), p = 0.033) were the best predictors of bone culture positivity. The area under the curve (AUC) for this multivariable model was 0.784 with sensitivity and specificity of 0.778 and 0.778, respectively. Interestingly, and contrary to popular belief, open wounds with exposed bone did not always yield positive bone cultures, and when cultures were positive, were not polymicrobial. Conclusions Aspiration of fluid at the time of biopsy and the presence of an open wound are the best predictors of positive bone cultures. |
| تدمد: | 1754-9485 1754-9477 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772659e3e6ff7781bf41aeebc664583fTest https://doi.org/10.1111/1754-9485.13012Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....772659e3e6ff7781bf41aeebc664583f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17549485 17549477 |
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