White matter network topology relates to cognitive flexibility and cumulative neurological risk in adult survivors of pediatric brain tumors
| العنوان: | White matter network topology relates to cognitive flexibility and cumulative neurological risk in adult survivors of pediatric brain tumors |
|---|---|
| المؤلفون: | Bruce Crosson, Tricia Z. King, Hui Mao, Vonetta M. Dotson, Longchuan Li, Tobey J. MacDonald, Sabrina Na |
| المصدر: | NeuroImage : Clinical NeuroImage: Clinical, Vol 20, Iss, Pp 485-497 (2018) |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Adolescent, Cognitive Neuroscience, Brain tumor survivorship, Brain tumor, lcsh:Computer applications to medicine. Medical informatics, Network topology, Cognitive flexibility, lcsh:RC346-429, Diffusion MRI, White matter, 03 medical and health sciences, Executive Function, Young Adult, 0302 clinical medicine, Physical medicine and rehabilitation, Cognition, Fractional anisotropy, Neural Pathways, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Long-term outcomes, Survivors, Young adult, Child, lcsh:Neurology. Diseases of the nervous system, Brain Mapping, business.industry, Brain Neoplasms, Brain, Regular Article, medicine.disease, White Matter, Graph theory, medicine.anatomical_structure, Diffusion Tensor Imaging, Neurology, 030220 oncology & carcinogenesis, lcsh:R858-859.7, Neurology (clinical), Nerve Net, business, Executive functioning, 030217 neurology & neurosurgery, Tractography |
| الوصف: | Adult survivors of pediatric brain tumors exhibit deficits in executive functioning. Given that brain tumors and medical treatments for brain tumors result in disruptions to white matter, a network analysis was used to explore the topological properties of white matter networks. This study used diffusion tensor imaging and deterministic tractography in 38 adult survivors of pediatric brain tumors (mean age in years = 23.11 (SD = 4.96), 54% female, mean years post diagnosis = 14.09 (SD = 6.19)) and 38 healthy peers matched by age, gender, handedness, and socioeconomic status. Nodes were defined using the Automated Anatomical Labeling (AAL) parcellation scheme, and edges were defined as the mean fractional anisotropy of streamlines that connected each node pair. Global efficiency and average clustering coefficient were reduced in survivors compared to healthy peers with preferential impact to hub regions. Global efficiency mediated differences in cognitive flexibility between survivors and healthy peers, as well as the relationship between cumulative neurological risk and cognitive flexibility. These results suggest that adult survivors of pediatric brain tumors, on average one and a half decades post brain tumor diagnosis and treatment, exhibit altered white matter topology in the form of suboptimal integration and segregation of large scale networks, and that disrupted topology may underlie executive functioning impairments. Network based studies provided important topographic insights on network organization in long-term survivors of pediatric brain tumor. Highlights • Long term brain tumor survivorship is associated with altered white matter networks. • Hub regions were preferentially impacted in survivors. • Network properties explain cognitive flexibility differences between survivors and peers. |
| اللغة: | English |
| تدمد: | 2213-1582 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76bf8d883cfd8549b1ddb50421d3627eTest http://europepmc.org/articles/PMC6105768Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....76bf8d883cfd8549b1ddb50421d3627e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22131582 |
|---|