Circulating Galectin-1 and 90K/Mac-2BP Correlated with the Tumor Stages of Patients with Colorectal Cancer
| العنوان: | Circulating Galectin-1 and 90K/Mac-2BP Correlated with the Tumor Stages of Patients with Colorectal Cancer |
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| المؤلفون: | Hong-Hwa Chen, Wen-Ling Yeh, Chang-Chun Hsiao, Keng-Liang Wu, Eng-Yen Huang, Chen-Tzi Pen, Kuender D. Yang |
| المصدر: | BioMed Research International BioMed Research International, Vol 2015 (2015) |
| بيانات النشر: | Hindawi Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Oncology, medicine.medical_specialty, animal structures, Article Subject, Galectin 1, Colorectal cancer, lcsh:Medicine, General Biochemistry, Genetics and Molecular Biology, Carcinoembryonic antigen, Antigen, Antigens, Neoplasm, Internal medicine, Tumor stage, Biomarkers, Tumor, otorhinolaryngologic diseases, medicine, Humans, Aged, Glycoproteins, Neoplasm Staging, Galectin, Aged, 80 and over, Membrane Glycoproteins, General Immunology and Microbiology, biology, business.industry, lcsh:R, Cancer, General Medicine, Middle Aged, medicine.disease, Clinical trial, stomatognathic diseases, Galectin-1, biology.protein, Female, Carrier Proteins, Colorectal Neoplasms, business, Research Article |
| الوصف: | Background. The simultaneous correlation of serum galectin-1, galectin-3, and 90K/Mac-2BP levels with clinical stages of patients with colorectal cancer has not yet been clarified. We plan to measure the serum levels of galectin-1, galectin-3, and 90K/Mac-2BP of patients at different stages of colorectal cancer and analyze the correlation of these galectins with stages of colorectal cancers.Methods. 198 colorectal cancer patients (62 ± 13 (range 31–85) years old, 43.6% female) were recruited for this study. Subjects’ blood samples were checked for serum galectin-1, galectin-3, 90K/Mac-2BP, and carcinoembryonic antigen by sandwich enzyme-linked immunosorbent assay. We determined the correlation between plasma concentrations with clinical tumor stages.Results. Colorectal cancer patients with larger cancer sizes (stages T3, T4 rather than T1, T2) have higher serum 90K/Mac-2BP (P= 0.014) and patients with lymph node metastasis have higher serum galectin-1 (P= 0.002) but there was not a significant correlation between galectin-3 and tumor staging of colon cancer. In colorectal cancer patients even with normal carcinoembryonic antigen, serum galectin-1 could predict more lymph node metastasis.Conclusions. We found 90K/Mac-2BP correlated with the size of colorectal cancer. Galectin-1 but not galectin-3 was associated with lymph node metastasis. Galectin-1 could predict more lymph node metastasis in colorectal cancer patients with normal serum carcinoembryonic antigen. |
| وصف الملف: | text/xhtml |
| تدمد: | 2314-6141 2314-6133 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b155d2a8ec6f96b93b323af738f3dcTest https://doi.org/10.1155/2015/306964Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....76b155d2a8ec6f96b93b323af738f3dc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
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