Metformin use is associated with a reduced risk of acute appendicitis in Taiwanese patients with type 2 diabetes mellitus
| العنوان: | Metformin use is associated with a reduced risk of acute appendicitis in Taiwanese patients with type 2 diabetes mellitus |
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| المؤلفون: | Chin-Hsiao Tseng |
| المصدر: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Reduced risk, medicine.medical_specialty, Science, Taiwan, 030209 endocrinology & metabolism, Drug Prescriptions, Article, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Diabetes mellitus, Internal medicine, medicine, Humans, Hypoglycemic Agents, 030212 general & internal medicine, Aged, Type 1 diabetes, Multidisciplinary, business.industry, Incidence, Hazard ratio, Gastroenterology, Type 2 Diabetes Mellitus, Retrospective cohort study, Middle Aged, medicine.disease, Appendicitis, Metformin, Diabetes Mellitus, Type 2, Acute appendicitis, Medicine, Female, business, medicine.drug |
| الوصف: | This retrospective cohort study used the nationwide database of Taiwan’s National Health Insurance to investigate whether metformin would reduce the risk of acute appendicitis in patients with type 2 diabetes mellitus. We first identified 423,949 patients newly diagnosed of diabetes from 1999 to 2005. After excluding patients having type 1 diabetes mellitus, missing data, previous history of acute appendicitis, aged 80 years and followed up for 50%. The benefit did not differ between different formulations of metformin, and the estimated hazard ratio for conventional/immediate-release metformin versus never users was 0.516 (0.441–0.603) and was 0.509 (0.421–0.615) for prolonged/slow-release metformin versus never users. It is concluded that metformin use is associated with a reduced risk of acute appendicitis in patients with type 2 diabetes mellitus. |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766c8c16f9f8a4d899470a0dee726382Test https://pubmed.ncbi.nlm.nih.gov/34117321Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....766c8c16f9f8a4d899470a0dee726382 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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