Association of microRNA 17 host gene variant (rs4284505) with susceptibility and severity of systemic lupus erythematosus
| العنوان: | Association of microRNA 17 host gene variant (rs4284505) with susceptibility and severity of systemic lupus erythematosus |
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| المؤلفون: | Nawal S. Gouda, Sameerah Shaheen, Rami M. Elshazli, Eman A. Toraih, Manal S. Fawzy, Nouf Abubakr Babteen, Abdelhady Ragab Abdel-Gawad |
| المصدر: | Immunity, Inflammation and Disease, Vol 8, Iss 4, Pp 595-604 (2020) Immunity, Inflammation and Disease |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, lcsh:Immunologic diseases. Allergy, Immunology, Mucocutaneous zone, Population, Lupus nephritis, MIR17HG, Epigenesis, Genetic, 03 medical and health sciences, Young Adult, 0302 clinical medicine, genetic polymorphisms, systemic lupus erythematosus, Genotype, Immunology and Allergy, Medicine, Humans, Lupus Erythematosus, Systemic, Genetic Predisposition to Disease, education, skin and connective tissue diseases, Original Research, education.field_of_study, rs4284505, business.industry, Heterozygote advantage, Odds ratio, Middle Aged, medicine.disease, Phenotype, Lupus Nephritis, MicroRNAs, 030104 developmental biology, Population study, Female, RNA, Long Noncoding, business, lcsh:RC581-607, 030215 immunology |
| الوصف: | Objective MicroRNAs are large family clusters of small noncoding RNAs that implicated in genetic and epigenetic regulation of several immunological processes and pathways. As an epigenetic modifier, the microRNA 17‐92 cluster host gene (MIR17HG) has been shown to regulate the expression of genes involved in systemic lupus erythematosus (SLE) pathway. This study aimed to explore the association of MIR17HG (rs4284505; A>G) variant with SLE development and phenotype in a sample of the Eastern Mediterranean population. Methods A total of 326 participants (163 patients with SLE and 163 healthy controls) were enrolled in this study. The different genotypes of the MIR17HG (rs4284505) variant were characterized using the TaqMan real‐time polymerase chain reaction technique. Association with the available clinical and laboratory data, including the systemic lupus erythematosus disease activity index (SLEDAI), was also executed. Results The MIR17HG (rs4284505) variant showed a protective effect against developing SLE under heterozygote (A/G vs A/A; odds ratio [OR] = 0.10, 95% confidence interval [CI] = 0.05‐0.20, P For the first time, this study showed that the microRNA 17‐92 cluster host gene (MIR17HG) is associated with the systemic lupus erythematosus (SLE) risk. The MIR17HG (A/G) genotype conferred a protective effect, while the (G/G) genotype showed increased susceptibility to SLE and association with the disease severity in a sample of the Eastern Mediterranean population. |
| اللغة: | English |
| تدمد: | 2050-4527 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765cb4c08f76bf3cdbaae0314650baadTest https://doaj.org/article/8469b8d3a4384bee97314c458619f60eTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....765cb4c08f76bf3cdbaae0314650baad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20504527 |
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