Mitochondrial Destabilisation and Caspase-3 Activation are Involved in the Apoptosis of Jurkat Cells Induced by Gaudichaudione A, a Cytotoxic Xanthone
| العنوان: | Mitochondrial Destabilisation and Caspase-3 Activation are Involved in the Apoptosis of Jurkat Cells Induced by Gaudichaudione A, a Cytotoxic Xanthone |
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| المؤلفون: | Swee-Hock Goh, Shugeng Cao, Anne Hsu, B. K. H. Tan, Xiao-Hua Wu |
| المصدر: | Planta Medica. 68:198-203 |
| بيانات النشر: | Georg Thieme Verlag KG, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Bridged-Ring Compounds, Stereochemistry, Xanthones, Pharmaceutical Science, Apoptosis, Caspase 3, DNA Fragmentation, Jurkat cells, Membrane Potentials, Analytical Chemistry, Jurkat Cells, Mice, chemistry.chemical_compound, Drug Discovery, Xanthone, Tumor Cells, Cultured, Animals, Humans, Cytotoxic T cell, Cytotoxicity, Caspase, Pharmacology, Dose-Response Relationship, Drug, biology, Plant Extracts, Organic Chemistry, Antineoplastic Agents, Phytogenic, Molecular biology, Mitochondria, Microscopy, Electron, Xanthenes, Complementary and alternative medicine, chemistry, Caspases, biology.protein, Molecular Medicine, DNA fragmentation, Garcinia |
| الوصف: | Gaudichaudione A, a cytotoxic xanthone obtained from Garcinia gaudichaudii, displayed strong growth inhibitory effects against Jurkat human leukemic cells, parental murine leukemic P388 and P388/DOX-resistant cell lines, and exhibited similar cytotoxicity against P388/DOX as well as P388, but was less toxic toward normal human Chang liver cells. A variety of apoptotic events induced by gaudichaudione A at the mitochondrial and nuclear levels has been characterized. It appears that gaudichaudione A induced a collapse of the mitochondrial transmembrane potential. Caspase-3 was activated and induced internucleosomal DNA fragmentation and externalization of PS residues. The apoptotic features were also observed in ultrastructural studies. |
| تدمد: | 1439-0221 0032-0943 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76007df5f828d51a936bd36d6afec311Test https://doi.org/10.1055/s-2002-23142Test |
| رقم الانضمام: | edsair.doi.dedup.....76007df5f828d51a936bd36d6afec311 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14390221 00320943 |
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