Telomere length, arsenic exposure and risk of basal cell carcinoma of skin
| العنوان: | Telomere length, arsenic exposure and risk of basal cell carcinoma of skin |
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| المؤلفون: | Tony Fletcher, Nalini Srinivas, Peter Rudnai, Thomas Hielscher, Rajesh Kumar, Eugene Gurzau, Silvia Calderazzo, Kvetoslava Koppova, Sivaramakrishna Rachakonda |
| المصدر: | Carcinogenesis. 40:715-723 |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Cancer Research, Skin Neoplasms, Physiology, chemistry.chemical_element, Polymorphism, Single Nucleotide, Arsenic, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Basal cell carcinoma, ARSENIC EXPOSURE, Aged, integumentary system, Arsenic toxicity, business.industry, Case-control study, Environmental Exposure, General Medicine, Odds ratio, Environmental exposure, Middle Aged, Telomere, medicine.disease, Increased risk, Endocrinology, 030104 developmental biology, chemistry, Carcinoma, Basal Cell, Case-Control Studies, 030220 oncology & carcinogenesis, Female, Skin cancer, business |
| الوصف: | Telomere length per se a heritable trait has been reported to be associated with different diseases including cancers. In this study based on arsenic exposed 528 cases with basal cell carcinoma of skin (BCC) and 533 healthy controls, we observed a statistically significant association between decreased telomere length and increased BCC risk (OR = 5.92, 95% CI = 3.92-9.01, P1.32 µg/L) was statistically significantly associated with decreased telomere length (β = −0.026, 95% CI = − 0.05-0.003, P = 0.02). The interaction between arsenic exposure and telomere length on BCC risk was statistically significant (P = 0.02). Within each tertile based on arsenic exposure, the individuals with shorter telomeres were at an increased risk of BCC, with highest risk being in the highest exposed group (OR = 16.13, 95% CI = 6.71-40.00, PP P = 0.0002). The combined effect of highest arsenic exposure and shortest telomeres on the risk of BCC (OR = 10.56, 95% CI = 5.14-21.70) showed a statistically significant departure from additivity (interaction constant ratio 6.56, P = 0.03). Our results show that in the presence of arsenic exposure, decreased telomere length predisposes individuals to increased risk of BCC, with the effect being synergistic in individuals with highest arsenic exposure and shortest telomeres. |
| تدمد: | 1460-2180 0143-3334 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cad81622becbc0c10f92572ee17e3eTest https://doi.org/10.1093/carcin/bgz059Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....75cad81622becbc0c10f92572ee17e3e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602180 01433334 |
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