Expression of toll-like receptors in non-endemic nasopharyngeal carcinoma
| العنوان: | Expression of toll-like receptors in non-endemic nasopharyngeal carcinoma |
|---|---|
| المؤلفون: | Caj Haglund, Heikki Minn, Jaana Hagström, Miia Ruuskanen, Tero Vahlberg, Ilmo Leivo, Heikki Irjala |
| المساهمون: | HUS Abdominal Center, Department of Surgery, II kirurgian klinikka, University Management, University of Helsinki, Research Programs Unit, CAN-PRO - Translational Cancer Medicine Program, Medicum, Department of Pathology, HUSLAB |
| المصدر: | BMC Cancer BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019) |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Herpesvirus 4, Human, Cancer Research, TUMOR-CELLS, Thyroid Gland, Kaplan-Meier Estimate, medicine.disease_cause, 0302 clinical medicine, INFECTION, TLR3, Child, Head and neck cancer, Papillomaviridae, Finland, Aged, 80 and over, Toll-like receptor, education.field_of_study, Toll-Like Receptors, Age Factors, virus diseases, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, Survival Rate, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, RNA, Viral, Immunohistochemistry, Female, SQUAMOUS-CELL CARCINOMA, Research Article, Adult, Human papillomavirus, Adolescent, 3122 Cancers, Population, lcsh:RC254-282, Young Adult, 03 medical and health sciences, INFLAMMATION, Nasopharyngeal carcinoma, Genetics, medicine, Humans, Epstein-Barr virus, education, POLYMORPHISMS, Cyclin-Dependent Kinase Inhibitor p16, Aged, business.industry, Cancer, Nasopharyngeal Neoplasms, Human papillomavirus 6, medicine.disease, Toll-Like Receptor 1, Epstein–Barr virus, Toll-Like Receptor 2, Toll-Like Receptor 4, Toll-Like Receptor 5, TLR2, 030104 developmental biology, Toll-Like Receptor 7, Toll-Like Receptor 9, Cancer research, Carcinogenesis, business |
| الوصف: | BackgroundNasopharyngeal carcinoma (NPC) is a malignant disease with an enigmatic etiology. NPC associates with Epstein-Barr virus (EBV) and human papillomaviruses (HPVs), while immunological factors also play a role in carcinogenesis. Toll-like receptors (TLRs) are pattern recognition receptors that participate in the immunological defence against pathogens, but their functions are also linked to cancer.MethodsIn our whole population-based study, we retrieved 150 Finnish NPC cases and studied their tumour samples for TLR1, TLR2, TLR4, TLR5, TLR7, and TLR9 expressions by immunohistochemistry, and for the presence of EBV and high-risk HPVs with EBV RNA and HPV E6/E7 mRNA in situ hybridizations. In addition, we analyzed the TLR expression patterns according to age, tumour histology, EBV/HPV status, and outcome.ResultsWe found that all TLRs studied were highly expressed in NPC. Viral status of the tumours varied, and 62% of them were EBV-positive, 14% HPV-positive, and 24% virus-negative. The tumours with strong TLR2(nucl) or TLR5 expression were mostly virus-negative or HPV-positive keratinizing squamous cell carcinomas, and the patients with these tumours were significantly older than those with mild or negative TLR2(nucl)/TLR5 expression. In Kaplan-Meier analysis, the patients with strong TLR5 expression had worse survival compared to the patients with negative or mild TLR5 expression, but the results were linked to other patient and tumour characteristics. In multivariable-adjusted Cox regression analysis, the patients with positive TLR7 tumour expression had better overall survival than those with no TLR7 expression. The 5-year overall survival rates according to TLR7 expression were 66% (mild), 52% (moderate or strong), and 22% (negative).ConclusionsTLRs are highly expressed in non-endemic NPC. Intensity of TLR2 and TLR5 expressions correlate with viral status, and TLR7 seems to be an independent prognostic factor of non-endemic NPC. |
| تدمد: | 1471-2407 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751d3064c2cbd546a2378c8fa768edf4Test https://doi.org/10.1186/s12885-019-5816-9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....751d3064c2cbd546a2378c8fa768edf4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712407 |
|---|