Brain MRI findings in relation to clinical characteristics and outcome of tuberculous meningitis
| العنوان: | Brain MRI findings in relation to clinical characteristics and outcome of tuberculous meningitis |
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| المؤلفون: | Sofiati Dian, Farhan Anwary, Rovina Ruslami, Ristaniah D. Soetikno, Tri Hanggono Achmad, Arjan van Laarhoven, Ahmad Rizal Ganiem, Sofia Immaculata, Robby Hermawan, Reinout van Crevel |
| المصدر: | PLoS ONE, Vol 15, Iss 11, p e0241974 (2020) PLoS ONE PLoS One, 15 PLoS One, 15, 11 |
| بيانات النشر: | Public Library of Science (PLoS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Physiology, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Antitubercular Agents, Infarction, Nervous System, Diagnostic Radiology, White Blood Cells, 0302 clinical medicine, Medical Conditions, Infectious Diseases of the Nervous System, Animal Cells, Medicine and Health Sciences, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Cerebrospinal Fluid, Multidisciplinary, medicine.diagnostic_test, Nerves, Radiology and Imaging, Cranial Nerves, Brain, Middle Aged, Magnetic Resonance Imaging, Body Fluids, Infectious Diseases, Neurology, Tuberculosis, Meningeal, Medicine, Female, Radiology, Anatomy, Cellular Types, Meningitis, Research Article, Hydrocephalus, Adult, Brain Infarction, medicine.medical_specialty, Adolescent, Imaging Techniques, Inflammatory Diseases, Immune Cells, Science, Immunology, Research and Analysis Methods, Tuberculous meningitis, 03 medical and health sciences, Young Adult, All institutes and research themes of the Radboud University Medical Center, Signs and Symptoms, Double-Blind Method, Diagnostic Medicine, medicine, Humans, Glasgow Coma Scale, Blood Cells, business.industry, Paradoxical reaction, Biology and Life Sciences, Magnetic resonance imaging, Cell Biology, medicine.disease, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], Lesions, Clinical Medicine, business, 030217 neurology & neurosurgery |
| الوصف: | Neuroradiological abnormalities in tuberculous meningitis (TBM) are common, but the exact relationship with clinical and inflammatory markers has not been well established. We performed magnetic resonance imaging (MRI) at baseline and after two months treatment to characterise neuroradiological patterns in a prospective cohort of adult TBM patients in Indonesia. We included 48 TBM patients (median age 30, 52% female, 8% HIV-infected), most of whom had grade II (90%), bacteriologically confirmed (71%) disease, without antituberculotic resistance. Most patients had more than one brain lesion (83%); baseline MRIs showed meningeal enhancement (89%), tuberculomas (77%), brain infarction (60%) and hydrocephalus (56%). We also performed an exploratory analysis associating MRI findings to clinical parameters, response to treatment, paradoxical reactions and survival. The presence of multiple brain lesion was associated with a lower Glasgow Coma Scale and more pronounced motor, lung, and CSF abnormalities (p-value |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75126e8b00da32fc97f56bf357273ea9Test https://doaj.org/article/12c69b3cefdf47b0bf0f4cc732d427dfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....75126e8b00da32fc97f56bf357273ea9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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