Subjective memory impairment and cholinergic transmission: a TMS study
| العنوان: | Subjective memory impairment and cholinergic transmission: a TMS study |
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| المؤلفون: | Arne C. Bathke, Eugen Trinka, Yvonne Höller, Frediano Tezzon, Piergiorgio Lochner, Peter Höller, Raffaele Nardone, Francesco Brigo |
| المصدر: | Journal of Neural Transmission. 122:873-876 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Neurology, medicine.medical_treatment, education, Prodromal Symptoms, Subjective memory, Synaptic Transmission, Alzheimer Disease, medicine, Humans, In patient, Neurons, Afferent, Cognitive impairment, Biological Psychiatry, Aged, Memory Disorders, medicine.disease, Transcranial Magnetic Stimulation, Cholinergic Neurons, Transcranial magnetic stimulation, Psychiatry and Mental health, Biomarker (medicine), Cholinergic, Female, Perception, Neurology (clinical), Alzheimer's disease, Psychology, Neuroscience |
| الوصف: | Subjective memory impairment (SMI) is being increasingly recognized as a preclinical phase of Alzheimer disease (AD). Short latency afferent inhibition (SAI) is helpful in demonstrating dysfunction of central cholinergic circuits, and was reported to be abnormal in patients with AD and amnestic multiple domain mild cognitive impairment. In this study, we found normal SAI in 20 subjects with SMI. SAI could be a useful biomarker for identifying, among individuals with memory complaints, those in whom cholinergic degeneration has occurred. |
| تدمد: | 1435-1463 0300-9564 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f2496e5fb93b2444e8945a192ea9e2Test https://doi.org/10.1007/s00702-014-1344-6Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....74f2496e5fb93b2444e8945a192ea9e2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14351463 03009564 |
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