Fine needle aspiration cytology of primary and metastatic gastrointestinal stromal tumour
| العنوان: | Fine needle aspiration cytology of primary and metastatic gastrointestinal stromal tumour |
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| المؤلفون: | Manish Rohilla, Gargi Kapatia, Parikshaa Gupta, Radhika Srinivasan, Pranab Dey, Arvind Rajwanshi, Ojas Gupta, Uma Nahar Saikia, Nalini Gupta |
| المصدر: | Cytopathology. 31:136-143 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, Histology, Adolescent, Gastrointestinal Stromal Tumors, Cytodiagnosis, Biopsy, Fine-Needle, Immunocytochemistry, Rectum, 030209 endocrinology & metabolism, Pathology and Forensic Medicine, Metastasis, Diagnosis, Differential, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Biomarkers, Tumor, medicine, Humans, Neoplasm Metastasis, neoplasms, Aged, Aged, 80 and over, GiST, business.industry, Stomach, Mediastinum, Neoplasms, Second Primary, General Medicine, Middle Aged, medicine.disease, digestive system diseases, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Duodenum, Female, business, Epithelioid cell |
| الوصف: | Aim To explore the cytological spectrum of the gastrointestinal stromal tumour (GIST) including its metastatic sites. Material and methods A total of 42 patients (45 sites) diagnosed with GIST or its metastases on fine needle aspiration cytology were studied over a period of 5 years. May-Grunwald Giemsa- and haematoxylin and eosin-stained smears were reviewed and analysed for the cytomorphological spectrum of GIST. Results Primary GIST alone was seen in 24 cases, E-GIST in eight cases and metastasis in 11 cases (one patient showing metastasis at two distinct sites), whereas concurrent primary and metastatic lesions were noted in two cases. Amongst primary sites, the most commonly affected location was stomach (n = 22), followed by ileum (n = 2), duodenum (n = 1) and rectum (n = 1). Extra-GIST was seen in retroperitoneum and pelvis (n = 3 each), omentum and mediastinum (n = 1 each). Fine needle aspiration cytology was done from 11 metastatic sites of GIST which included liver, gall bladder fossa, chest wall, and thigh. The classic spindle cell arrangement was the predominant cytological pattern. About 8.8% cases showed predominant epithelioid cell morphology and 15.5% cases had a mixed cytomorphology comprising of both spindle cell and epithelioid cell patterns. Nuclear pseudoinclusions, perinuclear vacuoles and multinucleation were seen in four cases. Immunocytochemistry on cell-block sections for confirmation was performed in 18 cases and all these cases showed strong c-KIT positivity. Conclusion In this largest case series of cytomorphological diagnosis of GIST, we describe the cytomorphology and immunocytochemistry of primary and metastatic GIST. GISTs with predominant epithelioid cell morphology may pose a diagnostic dilemma therefore in all suspected cases of GIST, immunocytochemistry for c-KIT and/or DOG1 should be employed on cell-block preparations to confirm the diagnosis of GIST. |
| تدمد: | 1365-2303 0956-5507 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c0311eeef623b2cd8a063ebfa16d53Test https://doi.org/10.1111/cyt.12785Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....74c0311eeef623b2cd8a063ebfa16d53 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652303 09565507 |
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