Acetylcholine and spinal locomotor networks: The insider
| العنوان: | Acetylcholine and spinal locomotor networks: The insider |
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| المؤلفون: | Camille Quilgars, Sandrine S. Bertrand, Théo Mille, Jean-René Cazalets |
| المساهمون: | Univ. Bordeaux, CNRS, EPHE, INCIA, UMR 5287 |
| المصدر: | Physiological Reports Physiological Reports, Wiley, 2021, 9, ⟨10.14814/phy2.14736⟩ Physiological Reports, Vol 9, Iss 3, Pp n/a-n/a (2021) |
| بيانات النشر: | HAL CCSD, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Physiology, [SDV]Life Sciences [q-bio], 030204 cardiovascular system & hematology, Biology, Neurotransmission, Receptors, Nicotinic, Synaptic Transmission, lcsh:Physiology, 03 medical and health sciences, 0302 clinical medicine, Postsynaptic potential, Physiology (medical), Muscarinic acetylcholine receptor, medicine, Animals, Humans, Invited Reviews, Cholinergic neuron, Spinal Cord Injuries, Invited Review, lcsh:QP1-981, Receptors, Muscarinic, Acetylcholine, 3. Good health, medicine.anatomical_structure, Nicotinic agonist, Metabotropic receptor, Spinal Nerves, Cholinergic Fibers, Spinal Cord, Neuron, Neuroscience, 030217 neurology & neurosurgery, Locomotion, medicine.drug |
| الوصف: | This article aims to review studies that have investigated the role of neurons that use the transmitter acetylcholine (ACh) in controlling the operation of locomotor neural networks within the spinal cord. This cholinergic system has the particularity of being completely intraspinal. We describe the different effects exerted by spinal cholinergic neurons on locomotor circuitry by the pharmacological activation or blockade of this propriospinal system, as well as describing its different cellular and subcellular targets. Through the activation of one ionotropic receptor, the nicotinic receptor, and five metabotropic receptors, the M1 to M5 muscarinic receptors, the cholinergic system exerts a powerful control both on synaptic transmission and locomotor network neuron excitability. Although tremendous advances have been made in our understanding of the spinal cholinergic system's involvement in the physiology and pathophysiology of locomotor networks, gaps still remain, including the precise role of the different subtypes of cholinergic neurons as well as their pre‐ and postsynaptic partners. Improving our knowledge of the propriospinal cholinergic system is of major relevance to finding new cellular targets and therapeutics in countering the debilitating effects of neurodegenerative diseases and restoring motor functions after spinal cord injury. This article aims to review studies that have investigated the role of neurons that use the transmitter acetylcholine in controlling the operation of locomotor neural networks within the spinal cord. |
| اللغة: | English |
| تدمد: | 2051-817X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748b3c4b5d7670ab96ff8b1487d3020dTest https://hal.archives-ouvertes.fr/hal-03131744Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....748b3c4b5d7670ab96ff8b1487d3020d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2051817X |
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