Analysis of the immune landscape of small bowel neuroendocrine tumors
| العنوان: | Analysis of the immune landscape of small bowel neuroendocrine tumors |
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| المؤلفون: | J. Strosberg, S Al Diffalha, Domenico Coppola, Mauro Cives |
| المصدر: | Endocr Relat Cancer |
| بيانات النشر: | Bioscientifica, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Cancer Research, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Carcinoid tumors, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Ileum, Neuroendocrine tumors, Gastroenterology, B7-H1 Antigen, Article, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Endocrinology, Immune system, Internal medicine, PD-L1, Intestinal Neoplasms, Immune Tolerance, medicine, Humans, Aged, Neoplasm Staging, Aged, 80 and over, biology, business.industry, Immunotherapy, Middle Aged, medicine.disease, Neuroendocrine Tumors, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Duodenum, biology.protein, Immunohistochemistry, Female, business |
| الوصف: | Immune checkpoint inhibitors have shown promising results in different cancers, and correlation between immune infiltration, expression of programmed death-ligand 1 (PD-L1) by tumor cells and response to immunotherapy has been reported. There is limited knowledge regarding the immune microenvironment of small bowel (SB) neuroendocrine tumors (NETs). This work was aimed at characterizing the immune landscape of SB NETs. Expression of PD-L1 and programmed death-1 (PD-1) was evaluated by immunohistochemistry in 102 surgically resected, primary NETs of the duodenum, jejunum and ileum. Extent and characteristics of the tumor-associated immune infiltrate were also assessed and investigated in their prognostic potential. We detected the expression of PD-L1 in ≥1 and ≥50% of tumor cells in 40/102 (39%; 95% CI, 30–49%) and 14/102 (14%; 95% CI, 8–22%) cases respectively. Intratumor host immune response was apparently absent in 35/102 cases (34%; 95% CI, 25–44%), mild to moderate in 46/102 samples (45%, 95% CI, 35–55%), intense in 21/102 tumors (21%, 95% CI, 13–30%). Expression of PD-L1 and extent of immune infiltration were significantly higher in duodenal NETs as compared with jejunal/ileal NETs. A marked peritumoral host response was organized as ectopic lymph node-like structures in 18/102 cases (18%; 95% CI, 11–26%). Neither PD-L1 expression nor the degree of immune infiltration showed any prognostic significance. Overall, the immune landscape of SB NETs is heterogeneous, with adaptive immune resistance mechanisms prevailing in duodenal NETs. Clinical trials of immune checkpoint inhibitors should take into account the immune heterogeneity of SB NETs. |
| تدمد: | 1479-6821 1351-0088 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7438c4a396980557e69a108693923bf2Test https://doi.org/10.1530/erc-18-0189Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7438c4a396980557e69a108693923bf2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14796821 13510088 |
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