Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course:a multi-cohort study
| العنوان: | Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course:a multi-cohort study |
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| المؤلفون: | Ahmed Elhakeem, Justiina Ronkainen, Toby Mansell, Katherine Lange, Tuija M. Mikkola, Binisha H. Mishra, Rama J. Wahab, Tim Cadman, Tiffany Yang, David Burgner, Johan G. Eriksson, Marjo-Riitta Järvelin, Romy Gaillard, Vincent W. V. Jaddoe, Terho Lehtimäki, Olli T. Raitakari, Richard Saffery, Melissa Wake, John Wright, Sylvain Sebert, Deborah A. Lawlor |
| المساهمون: | Pediatrics, Clinicum, University of Helsinki, Faculty of Medicine, Research Programs Unit, Johan Eriksson / Principal Investigator, Department of General Practice and Primary Health Care, Tampere University, Clinical Medicine, Department of Clinical Chemistry |
| المصدر: | Elhakeem, A, Ronkainen, J, Mansell, T, Lange, K, Mikkola, T M, Mishra, B H, Wahab, R J, Cadman, T, Yang, T, Burgner, D, Eriksson, J G, Järvelin, M R, Gaillard, R, Jaddoe, V W V, Lehtimäki, T, Raitakari, O T, Saffery, R, Wake, M, Wright, J, Sebert, S & Lawlor, D A 2023, ' Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course : a multi-cohort study ', BMC Medicine, vol. 21, no. 1, 23 . https://doi.org/10.1186/s12916-022-02711-8Test BMC Medicine, 21(1):23. BioMed Central Ltd. medRxiv |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | SDG 3 - Good Health and Well-being, 3123 Gynaecology and paediatrics, 3121 General medicine, internal medicine and other clinical medicine, Cohort, Metabolomics, Life course, 3111 Biomedicine, General Medicine |
| الوصف: | BackgroundCommon pregnancy and perinatal complications are associated with offspring cardiometabolic risk factors. These complications may influence multiple metabolic traits in the offspring and these associations might differ with offspring age.MethodsWe used data from eight population-based cohort studies to examine and compare associations of pre-eclampsia (PE), gestational hypertension (GH), gestational diabetes (GD), preterm birth (PTB), small (SGA) and large (LGA) for gestational age (vs. appropriate size for gestational age (AGA)) with up to 167 plasma/serum-based nuclear magnetic resonance-derived metabolic traits encompassing lipids, lipoproteins, fatty acids, amino acids, ketones, glycerides/phospholipids, glycolysis, fluid balance, and inflammation. Confounder-adjusted regression models were used to examine associations (adjusted for maternal education, parity age at pregnancy, ethnicity, pre/early pregnancy body mass index and smoking, and offspring sex and age at metabolic trait assessment), and results were combined using meta-analysis by five age categories representing different periods of the offspring life course: neonates (cord blood), infancy (mean ages: 1.1–1.6 years), childhood (4.2–7.5 years); adolescence (12.0–16.0 years), and adulthood (22.0–67.8 years).ResultsOffspring numbers for each age category/analysis varied from 8925 adults (441 PTB) to 1181 infants (135 GD); 48.4% to 60.0% were females. Pregnancy complications (PE, GH, GD) were each associated with up to three metabolic traits in neonates (P≤0.001) with some evidence of persistence to older ages. PTB and SGA were associated with 32 and 12 metabolic traits in neonates respectively, which included an adjusted standardised mean difference of −0.89 standard deviation (SD) units for albumin with PTB (95% CI: −1.10 to −0.69, P=1.3×10−17) and −0.41 SD for total lipids in medium HDL with SGA (95% CI: −0.56 to −0.25, P=2.6×10−7), with some evidence of persistence to older ages. LGA was inversely associated with 19 metabolic traits including lower levels of cholesterol, lipoproteins, fatty acids, and amino acids, with associations emerging in adolescence, (e.g. −0.11 SD total fatty acids, 95% CI: −0.18 to −0.05, P=0.0009), and attenuating with older age across adulthood Background: Common pregnancy and perinatal complications are associated with offspring cardiometabolic risk factors. These complications may influence multiple metabolic traits in the offspring and these associations might differ with offspring age. Methods: We used data from eight population-based cohort studies to examine and compare associations of pre-eclampsia (PE), gestational hypertension (GH), gestational diabetes (GD), preterm birth (PTB), small (SGA) and large (LGA) for gestational age (vs. appropriate size for gestational age (AGA)) with up to 167 plasma/serum-based nuclear magnetic resonance-derived metabolic traits encompassing lipids, lipoproteins, fatty acids, amino acids, ketones, glycerides/phospholipids, glycolysis, fluid balance, and inflammation. Confounder-adjusted regression models were used to examine associations (adjusted for maternal education, parity age at pregnancy, ethnicity, pre/early pregnancy body mass index and smoking, and offspring sex and age at metabolic trait assessment), and results were combined using meta-analysis by five age categories representing different periods of the offspring life course: neonates (cord blood), infancy (mean ages: 1.1–1.6 years), childhood (4.2–7.5 years); adolescence (12.0–16.0 years), and adulthood (22.0–67.8 years). Results: Offspring numbers for each age category/analysis varied from 8925 adults (441 PTB) to 1181 infants (135 GD); 48.4% to 60.0% were females. Pregnancy complications (PE, GH, GD) were each associated with up to three metabolic traits in neonates (P≤0.001) with some evidence of persistence to older ages. PTB and SGA were associated with 32 and 12 metabolic traits in neonates respectively, which included an adjusted standardised mean difference of −0.89 standard deviation (SD) units for albumin with PTB (95% CI: −1.10 to −0.69, P=1.3×10−17) and −0.41 SD for total lipids in medium HDL with SGA (95% CI: −0.56 to −0.25, P=2.6×10−7), with some evidence of persistence to older ages. LGA was inversely associated with 19 metabolic traits including lower levels of cholesterol, lipoproteins, fatty acids, and amino acids, with associations emerging in adolescence, (e.g. −0.11 SD total fatty acids, 95% CI: −0.18 to −0.05, P=0.0009), and attenuating with older age across adulthood. Conclusions: These reassuring findings suggest little evidence of wide-spread and long-term impact of common pregnancy and perinatal complications on offspring metabolic traits, with most associations only observed for newborns rather than older ages, and for perinatal rather than pregnancy complications. |
| وصف الملف: | application/pdf; fulltext |
| اللغة: | English |
| تدمد: | 1741-7015 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a0e1789b6c5e001499c799fe7694eaTest https://curis.ku.dk/ws/files/334392360/Fulltext.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....73a0e1789b6c5e001499c799fe7694ea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17417015 |
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