Altered left ventricular performance in aging physically active mice with an ankle sprain injury
| العنوان: | Altered left ventricular performance in aging physically active mice with an ankle sprain injury |
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| المؤلفون: | Joseph S. Marino, Erik A. Wikstrom, Tricia Hubbard-Turner, Sophie Guderian, Joshua R. Huot, Bailey Peck, Susan T Arthur, Michael J. Turner |
| المصدر: | AGE. 38 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Aging, medicine.medical_specialty, Physical Exertion, Diastole, Male mice, 030204 cardiovascular system & hematology, Ventricular Function, Left, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Animals, Ankle Injuries, Sedentary lifestyle, E/A ratio, business.industry, 030229 sport sciences, General Medicine, Surgery, Disease Models, Animal, Isoflurane, Sedentary group, Mice, Inbred CBA, Cardiology, Velocity ratio, Geriatrics and Gerontology, business, Ankle sprain, Blood Flow Velocity, medicine.drug |
| الوصف: | We assessed the impact of differing physical activity levels throughout the lifespan, using a musculoskeletal injury model, on the age-related changes in left ventricular (LV) parameters in active mice. Forty male mice (CBA/J) were randomly placed into one of three running wheel groups (transected CFL group, transected ATFL/CFL group, SHAM group) or a SHAM Sedentary group (SHAMSED). Before surgery and every 6 weeks after surgery, LV parameters were measured under 2.5 % isoflurane inhalation. Group effects for daily distance run was significantly greater for the SHAM and lesser for the ATLF/CFL mice (p = 0.013) with distance run decreasing with age for all mice (p |
| تدمد: | 1574-4647 0161-9152 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739aef6b244aa2568c07de99d5a65859Test https://doi.org/10.1007/s11357-016-9877-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....739aef6b244aa2568c07de99d5a65859 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15744647 01619152 |
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