EFFECT OF IL-18 ON THE RELEASE OF IL-6 AND ITS SOLUBLE RECEPTORS: sIL-6RαAND sgp130 BY HUMAN NEUTROPHILS
| العنوان: | EFFECT OF IL-18 ON THE RELEASE OF IL-6 AND ITS SOLUBLE RECEPTORS: sIL-6RαAND sgp130 BY HUMAN NEUTROPHILS |
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| المؤلفون: | J. Jablonski, E. Jablonska |
| المصدر: | Immunological Investigations. 31:159-167 |
| بيانات النشر: | Informa UK Limited, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Neutrophils, medicine.drug_class, Immunology, Interleukin 1 receptor, type II, Pharmacology, Proinflammatory cytokine, Antigens, CD, Internal medicine, Cytokine Receptor gp130, medicine, Humans, Secretion, Interleukin 6, Receptor, Cells, Cultured, Inflammation, Membrane Glycoproteins, biology, Interleukin-6, Interleukin-18, General Medicine, Receptor antagonist, Receptors, Interleukin-6, Recombinant Proteins, Endocrinology, Solubility, Culture Media, Conditioned, biology.protein, Interleukin 18, Interleukin 1 receptor, type I |
| الوصف: | The biological activities of IL-18 include its ability to induce the production of inflammatory cytokines such as IL-1 or IL-8 by immunocompetent cells. Our previous study demonstrated that rhIL-18 induces IL-1beta and, to a lesser exted, the secretion of IL-1beta regulatory proteins involving interleukin-1 receptor antagonist (IL-IRa) and soluble interleukin-1 receptor II (sIL-1RII) by neutrophils (PMN), suggesting a significant role of IL-18 in the reactions mediated by IL-1beta. In this study, we estimated the effect of rhIL-18 on the induction of IL-6 and its soluble receptors - sIL-6Ralpha and sgp130 by these cells. Results obtained indicate that IL-18 is a promising candidate for the enhanced secretion of IL-6 by human neutrophils. In contrast, we have not found a significant effect of IL-18 on the release of both soluble receptors of IL-6. The influence of IL-18 on the IL-6 production by PMN appears to indicate a potential role of IL-18 in the early steps of the inflammatory cascade and other immune reactions mediated by IL-6. |
| تدمد: | 1532-4311 0882-0139 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739803cd403bb00070a82e14468b519cTest https://doi.org/10.1081/imm-120016237Test |
| رقم الانضمام: | edsair.doi.dedup.....739803cd403bb00070a82e14468b519c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15324311 08820139 |
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