Paradoxical effects of DNA tumor virus oncogenes on epithelium-derived tumor cell fate during tumor progression and chemotherapy response
| العنوان: | Paradoxical effects of DNA tumor virus oncogenes on epithelium-derived tumor cell fate during tumor progression and chemotherapy response |
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| المؤلفون: | Yitao Mao, Hong Zhu, Zhi Xiao, Liyu Liu, Zhi Li, Lu Zhang, You Zhou, Lun-Quan Sun, Jiang He, Mu Sheng Zeng, Can Lu, Deyun Feng, Huan Liu, Liang Weng, Yuemei Duan, Feiyu Tang |
| المصدر: | Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-16 (2021) Signal Transduction and Targeted Therapy |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Epstein-Barr Virus Infections, Herpesvirus 4, Human, endocrine system, Cancer Research, QH301-705.5, medicine.medical_treatment, Uterine Cervical Neoplasms, Antineoplastic Agents, Article, Virus, Viral Matrix Proteins, Mice, chemistry.chemical_compound, In vivo, Genetics, medicine, Animals, Humans, Tumour virus infections, Biology (General), Papillomaviridae, Cancer, Chemotherapy, Nasopharyngeal Carcinoma, business.industry, Papillomavirus Infections, Nasopharyngeal Neoplasms, Oncogene Proteins, Viral, medicine.disease, Xenograft Model Antitumor Assays, Epithelium, medicine.anatomical_structure, chemistry, Nasopharyngeal carcinoma, Tumor progression, Cancer cell, Cancer research, Medicine, Female, business, DNA, HeLa Cells |
| الوصف: | Epstein-Barr virus (EBV) and human papillomavirus (HPV) infection is the risk factors for nasopharyngeal carcinoma and cervical carcinoma, respectively. However, clinical analyses demonstrate that EBV or HPV is associated with improved response of patients, although underlying mechanism remains unclear. Here, we reported that the oncoproteins of DNA viruses, such as LMP1 of EBV and E7 of HPV, inhibit PERK activity in cancer cells via the interaction of the viral oncoproteins with PERK through a conserved motif. Inhibition of PERK led to increased level of reactive oxygen species (ROS) that promoted tumor and enhanced the efficacy of chemotherapy in vivo. Consistently, disruption of viral oncoprotein-PERK interactions attenuated tumor growth and chemotherapy in both cancer cells and tumor-bearing mouse models. Our findings uncovered a paradoxical effect of DNA tumor virus oncoproteins on tumors and highlighted that targeting PERK might be an attractive strategy for the treatment of NPC and cervical carcinoma. |
| تدمد: | 2059-3635 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7340e68a58781a773def8e089e060d4aTest https://doi.org/10.1038/s41392-021-00787-xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7340e68a58781a773def8e089e060d4a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20593635 |
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