Expression of drug resistance related proteins in sarcomas of the pulmonary artery and poorly differentiated leiomyosarcomas of other origin
| العنوان: | Expression of drug resistance related proteins in sarcomas of the pulmonary artery and poorly differentiated leiomyosarcomas of other origin |
|---|---|
| المؤلفون: | Charles James Kirkpatrick, Thomas Mentzel, Eckhard Mayer, Peter K. Petrow, Andreas Gaumann, Mike Otto, D. S. Tews, Jörg Kriegsmann |
| المصدر: | Virchows Archiv. 442:529-537 |
| بيانات النشر: | Springer Science and Business Media LLC, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Adult, Leiomyosarcoma, Male, Pathology, medicine.medical_specialty, ATP Binding Cassette Transporter, Subfamily B, medicine.medical_treatment, Drug resistance, Pulmonary Artery, Biology, Pathology and Forensic Medicine, Downregulation and upregulation, Antigens, Neoplasm, medicine, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Molecular Biology, Aged, Vault Ribonucleoprotein Particles, Topoisomerase, Drug detoxification, Cell Biology, General Medicine, Middle Aged, medicine.disease, Phenotype, Neoplasm Proteins, DNA-Binding Proteins, Survival Rate, DNA Topoisomerases, Type II, Drug Resistance, Neoplasm, Neoplasms, Vascular Tissue, Cancer research, biology.protein, Immunohistochemistry, Female, Metallothionein, Sarcoma |
| الوصف: | Sarcomas are known to develop resistance to current chemotherapeutic strategies, displaying a multidrug-resistant phenotype. Mechanisms involved in drug resistance include reduced cellular drug accumulation, drug detoxification as well as alterations in drug target specificity. In seven sarcomas of the pulmonary artery (SPA) and ten leiomyosarcomas of other origin, we studied the immunohistochemical expression of P-glycoprotein (P-gp), multidrug-resistance protein (MRP), lung resistance protein (LRP), metallothionein (MT) and topoisomerase IIalpha. Upregulation was found in tumour cells for P-gp but not for MRP in SPA and other leiomyosarcomas. Topoisomerase IIalpha was expressed at high levels in tissue of primary tumours as well as recurrent tumours. Both P-gp and topoisomerase IIalpha were present in numerous tumour-associated vessels. LRP was expressed at high levels in SPA but to a lesser extent in the other leiomyosarcomas. MT was expressed at low levels but was markedly present at the border of necrosis. The overall survival and the relapse-free survival did not correlate with the expression of these factors. There was no significant relationship between treated and non-treated patients with respect to the expression of the examined molecules. P-gp, but not MRP, may play a role in the development of drug resistance. P-gp, LRP and topoisomerase IIalpha contribute to drug resistance through expression in tumour-associated vessels. Unique high levels of topisomerase IIalpha reflect the high proliferation rate of these tumours. MT seems to serve as a detoxifying agent of metabolites at the border of necrosis. Our findings underline the fact that multiple factors contribute to chemoresistance and that examination of a spectrum of relevant molecules is probably necessary to plan the best therapy. |
| تدمد: | 1432-2307 0945-6317 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731b660c0a3c767dac9f3b6cd921f127Test https://doi.org/10.1007/s00428-003-0815-1Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....731b660c0a3c767dac9f3b6cd921f127 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14322307 09456317 |
|---|