Urothelial effects of oral agents for overactive bladder
| العنوان: | Urothelial effects of oral agents for overactive bladder |
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| المؤلفون: | Roberto Soler, Claudius Füllhase, Karl-Erik Andersson |
| المصدر: | Current Urology Reports. 9:459-464 |
| بيانات النشر: | Springer Science and Business Media LLC, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Urinary Bladder, Overactive, business.industry, Urology, Administration, Oral, Sensory system, Muscarinic Antagonists, General Medicine, Pharmacology, medicine.disease, Overactive bladder, Muscarinic acetylcholine receptor, Humans, Medicine, Myocyte, Tolterodine, Urothelium, Signal transduction, business, Receptor, Oxybutynin, medicine.drug |
| الوصف: | The cholinergic system of the bladder includes muscarinic receptors distributed to detrusor myocytes and structures within mucosa including bladder afferent (sensory) nerves. The receptors have been shown to be involved in afferent signaling from the bladder, but it has not been established to what extent effects on this mucosal signaling pathway contribute to the therapeutic efficacy of the clinically used antimuscarinics. Mucosa can be influenced by antimuscarinics via the bloodstream. However, some antimuscarinics and their active metabolites are excreted in urine in amounts that may affect the mucosal muscarinic receptors from the luminal side. This has not yet been demonstrated to imply superior clinical efficacy. Nevertheless, mucosal afferent signaling pathways are therapeutically interesting targets that should be further explored. |
| تدمد: | 1534-6285 1527-2737 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e15beccfca215fa4ecc1872e4fa03aTest https://doi.org/10.1007/s11934-008-0079-zTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....72e15beccfca215fa4ecc1872e4fa03a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15346285 15272737 |
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