Two New Terpenes Isolated from Dictyostelium Cellular Slime Molds
| العنوان: | Two New Terpenes Isolated from Dictyostelium Cellular Slime Molds |
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| المؤلفون: | Hirotaka Ishigaki, Haruhisa Kikuchi, Hiromi Eguchi, Yoshiteru Oshima, Akihiro Sugawara, Yuzuru Kubohara, Katsunori Takahashi, Hitomi Sasaki |
| المصدر: | Molecules, Vol 25, Iss 2895, p 2895 (2020) Molecules Volume 25 Issue 12 |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Staphylococcus aureus, Magnetic Resonance Spectroscopy, natural products, dictyostelid, Pharmaceutical Science, Antineoplastic Agents, Microbial Sensitivity Tests, Sesquiterpene, 01 natural sciences, Article, Analytical Chemistry, Terpene, lcsh:QD241-441, Inhibitory Concentration 50, Mice, 03 medical and health sciences, chemistry.chemical_compound, lcsh:Organic chemistry, Osteogenesis, terpenoids, Drug Discovery, Escherichia coli, Slime mold, Animals, Humans, Dictyostelium, Physical and Theoretical Chemistry, 030304 developmental biology, Dictyostelid, 0303 health sciences, Natural product, biology, Terpenes, 010405 organic chemistry, Organic Chemistry, fungi, cellular slime molds, biology.organism_classification, Terpenoid, Anti-Bacterial Agents, Biosynthetic Pathways, 0104 chemical sciences, RAW 264.7 Cells, chemistry, Biochemistry, Chemistry (miscellaneous), Molecular Medicine, HeLa Cells |
| الوصف: | We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by several spectral means. Mucoroidiol and firmibasiol are the first examples of more modified and oxidized terpenoids isolated from cellular slime molds. Mucoroidiol showed moderate osteoclast-differentiation inhibitory activity despite demonstrating very weak cell-proliferation inhibitory activity. Therefore, cellular slime molds produce considerably diverse secondary metabolites, and they are promising sources of new natural product chemistry. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1420-3049 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728034f743f71ed8a6a664459aec8748Test https://www.mdpi.com/1420-3049/25/12/2895Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....728034f743f71ed8a6a664459aec8748 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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