TILs and Anti-PD1 Therapy: An Alternative Combination Therapy for PDL1 Negative Metastatic Cervical Cancer
| العنوان: | TILs and Anti-PD1 Therapy: An Alternative Combination Therapy for PDL1 Negative Metastatic Cervical Cancer |
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| المؤلفون: | Huanhuan Yin, Cuihua Feng, Yujie Tan, Xiangling Sun, Wei Guo, Ruili Li |
| المصدر: | Journal of Immunology Research, Vol 2020 (2020) Journal of Immunology Research |
| بيانات النشر: | Hindawi Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Cytotoxicity, Immunologic, Oncology, medicine.medical_specialty, Multivariate analysis, Article Subject, Combination therapy, Programmed Cell Death 1 Receptor, Immunology, Uterine Cervical Neoplasms, Kaplan-Meier Estimate, B7-H1 Antigen, Immunophenotyping, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, medicine, Overall survival, Humans, Immunology and Allergy, In patient, Molecular Targeted Therapy, Anti pd1, Immune Checkpoint Inhibitors, Objective response, Metastatic cervical cancer, Aged, business.industry, General Medicine, Middle Aged, RC581-607, Prognosis, Magnetic Resonance Imaging, Treatment Outcome, 030220 oncology & carcinogenesis, Cytokines, Female, Immunologic diseases. Allergy, Tomography, X-Ray Computed, business, Research Article, 030215 immunology |
| الوصف: | Background. We investigated the efficacy of TILs and anti-PD1 combination therapy in patients with metastatic cervical cancer with low MSI expression and PDL1-negative. Methods. A total of 80 patients were put on TILs and anti-PD1 combination therapy, and the progression-free survival time (PFS) and overall survival time (OS) were assessed by Kaplan–Meier analysis. Univariate and multivariate analyses were performed to identify factors that could predict the prognosis of metastatic cervical cancer in the previously described patients. Results. The objective response rate was 25%, whereas the mPFS and mOS were 6.1 and 11.3 months, respectively. The therapeutic efficacy was influenced by the characteristics of TILs, infection with HPV, and development of fever just after the therapy. Conclusion. Overall, our results show that the combination therapy of TILs and anti-PD1 significantly improves the prognosis of metastatic cervical cancer. |
| وصف الملف: | text/xhtml |
| تدمد: | 2314-7156 2314-8861 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721b2d90497b5fff7641c5df3560f9cdTest https://doi.org/10.1155/2020/8345235Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....721b2d90497b5fff7641c5df3560f9cd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23147156 23148861 |
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