Lower White Matter Volume and Worse Executive Functioning Reflected in Higher Levels of Plasma GFAP among Older Adults with and Without Cognitive Impairment
| العنوان: | Lower White Matter Volume and Worse Executive Functioning Reflected in Higher Levels of Plasma GFAP among Older Adults with and Without Cognitive Impairment |
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| المؤلفون: | Nicole C. Fernandes, Lawren VandeVrede, Fanny M. Elahi, Michelle You, Cutter A. Lindbergh, Bruce L. Miller, Howie Rosen, Julio C. Rojas, Adam L. Boxer, Joel H. Kramer, Sophia Weiner-Light, Corrina Fonseca, Adam M. Staffaroni, Nivetha Brathaban, Breton M Asken, Alexandra C. Apple, Kaitlin B. Casaletto |
| المصدر: | Journal of the International Neuropsychological Society : JINS, vol 28, iss 6 J Int Neuropsychol Soc |
| بيانات النشر: | Cambridge University Press (CUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Aging, Intermediate Filaments, Neurodegenerative, Alzheimer's Disease, Medical and Health Sciences, Executive Function, Neurofilament Proteins, 80 and over, Cognitive impairment, Aged, 80 and over, Glial fibrillary acidic protein, biology, General Neuroscience, Neurodegenerative Diseases, Experimental Psychology, Cognition, Middle Aged, Alzheimer's, White Matter, Pathophysiology, Psychiatry and Mental health, Clinical Psychology, medicine.anatomical_structure, Neurological, Cohort, Brain size, Mental health, Astrocyte, medicine.medical_specialty, Article, White matter, Alzheimer Disease, Clinical Research, Internal medicine, Glial Fibrillary Acidic Protein, Acquired Cognitive Impairment, medicine, Humans, Dementia, Cognitive Dysfunction, Aged, business.industry, Psychology and Cognitive Sciences, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), medicine.disease, Brain Disorders, Endocrinology, biology.protein, Neurology (clinical), business, Biomarkers, Alzheimer’s |
| الوصف: | Objective:There are minimal data directly comparing plasma neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) in aging and neurodegenerative disease research. We evaluated associations of plasma NfL and plasma GFAP with brain volume and cognition in two independent cohorts of older adults diagnosed as clinically normal (CN), mild cognitive impairment (MCI), or Alzheimer’s dementia.Methods:We studied 121 total participants (Cohort 1: n = 50, age 71.6 ± 6.9 years, 78% CN, 22% MCI; Cohort 2: n = 71, age 72.2 ± 9.2 years, 45% CN, 25% MCI, 30% dementia). Gray and white matter volumes were obtained for total brain and broad subregions of interest (ROIs). Neuropsychological testing evaluated memory, executive functioning, language, and visuospatial abilities. Plasma samples were analyzed in duplicate for NfL and GFAP using single molecule array assays (Quanterix Simoa). Linear regression models with structural MRI and cognitive outcomes included plasma NfL and GFAP simultaneously along with relevant covariates.Results:Higher plasma GFAP was associated with lower white matter volume in both cohorts for temporal (Cohort 1: β = −0.33, p = .002; Cohort 2: β = −0.36, p = .03) and parietal ROIs (Cohort 1: β = −0.31, p = .01; Cohort 2: β = −0.35, p = .04). No consistent findings emerged for gray matter volumes. Higher plasma GFAP was associated with lower executive function scores (Cohort 1: β = −0.38, p = .01; Cohort 2: β = −0.36, p = .007). Plasma NfL was not associated with gray or white matter volumes, or cognition after adjusting for plasma GFAP.Conclusions:Plasma GFAP may be more sensitive to white matter and cognitive changes than plasma NfL. Biomarkers reflecting astroglial pathophysiology may capture complex dynamics of aging and neurodegenerative disease. |
| وصف الملف: | application/pdf |
| تدمد: | 1469-7661 1355-6177 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71aa140b7de1cc2817251682a488ac81Test https://doi.org/10.1017/s1355617721000813Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....71aa140b7de1cc2817251682a488ac81 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14697661 13556177 |
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