The Circulating Fatty Acid Transporter Soluble CD36 Is Not Associated with Carotid Atherosclerosis in Subjects with Type 1 and Type 2 Diabetes Mellitus
| العنوان: | The Circulating Fatty Acid Transporter Soluble CD36 Is Not Associated with Carotid Atherosclerosis in Subjects with Type 1 and Type 2 Diabetes Mellitus |
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| المؤلفون: | Marta Hernández, Didac Mauricio, Maria Barranco-Altirriba, Lucía Sanjurjo, Esmeralda Castelblanco, Mireia Falguera, Núria Alonso, Berta Soldevila, Josep Franch-Nadal, Maria-Rosa Sarrias, José Manuel Fernández-Real, Juan Antonio Arroyo |
| المصدر: | Journal of Clinical Medicine r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol instname Journal of Clinical Medicine, Vol 9, Iss 1700, p 1700 (2020) Volume 9 Issue 6 Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Repositorio Abierto de la UdL Universitad de Lleida r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, systolic blood pressure, type 2 diabetes mellitus, CD36, carotid atherosclerosis, lcsh:Medicine, Type 2 diabetes, 030204 cardiovascular system & hematology, atherosclerotic plaque, 0302 clinical medicine, CD36 antigen, Subclinical infection, chemistry.chemical_classification, clinical article, biology, messenger RNA, non insulin dependent diabetes mellitus, adult, General Medicine, aged, female, real time polymerase chain reaction, Biomarker (medicine), cardiovascular risk, medicine.medical_specialty, hypertension, alanine aminotransferase, alcohol consumption, insulin dependent diabetes mellitus, Type 2diabetes mellitus, Article, glyceraldehyde 3 phosphate dehydrogenase, 03 medical and health sciences, male, Internal medicine, Diabetes mellitus, fatty acid transporter, medicine, cross-sectional study, human, Type 1 diabetes, mean platelet volume, business.industry, flow cytometry, disease association, lcsh:R, echography, Type 2 Diabetes Mellitus, Fatty acid, medicine.disease, sCD36, body mass, 030104 developmental biology, Endocrinology, chemistry, gene expression, biology.protein, business, type 1 diabetes mellitus |
| الوصف: | This study aimed to determine the association of fatty acid transporter plasma solublecluster of differentiation 36 (sCD36) with subclinical carotid atherosclerosis (SCA). A cross-sectionalstudy was conducted in 1023 subjects, 225 with type 1 diabetes (T1D), 276 with type 2 diabetes (T2D)and 522 who were nondiabetic. Carotid atherosclerotic plaque (CAP) presence was determined usingB-mode carotid ultrasound imaging. sCD36 were analysed by ELISA, and CD36 surface receptor andmRNA expression were measured by flow cytometry and real-time PCR. Logistic regression modelswere used to evaluate sCD36 as a biomarker of SCA. Up to 376 (36.75%) participants had at least oneCAP, 76 T1D, 164 T2D and 136 without diabetes, while the remaining 647 (63.25%) did not have anyCAP. There were no differences in sCD36 between patients with and without CAP in T1D (p=0.287)or T2D (p=0.513). Although nondiabetic subjects with plaques had lower sCD36 levels than thosewithout (p=0.023), the multivariate models revealed no association of sCD36 with CAP in any of thethree study groups. No differences were found in surface CD36 or CD36 mRNA expression between the patients with and without CAP. sCD36 is not associated with SCA in type 1 or type 2 diabetic orin nondiabetic subjects. This research was supported by grants from the European Foundation for the study of diabetes (2014-EFSD-00914) and European Regional Development Fund (ERDF). CIBER for Diabetes and Associated Metabolic Diseases (CIBERDEM), CIBER on Liver and Digestive Diseases (CIBEREHD), and CIBER on Physiopathology ofObesity and Nutrition (CIBEROBN) are initiatives of the Carlos III National Institute of Health, Spain. |
| وصف الملف: | application/pdf |
| تدمد: | 2077-0383 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cf486215bc2a753cb8863e507ebae4Test https://fundanet.igtp.cat/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3433Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....70cf486215bc2a753cb8863e507ebae4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20770383 |
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