The emerging role of ISWI chromatin remodeling complexes in cancer
| العنوان: | The emerging role of ISWI chromatin remodeling complexes in cancer |
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| المؤلفون: | Yajuan Cui, Yu Zhu, Pan Wang, Yanan Li, Jing Liu, Han Gong, Heng Li, Hongling Peng, Zi Wang |
| المصدر: | Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-27 (2021) Journal of Experimental & Clinical Cancer Research : CR |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer Research, Review, Biology, ISWI family, medicine.disease_cause, Chromatin remodeling, Mice, Neoplasms, Gene expression, medicine, Transcriptional regulation, Animals, Humans, Epigenetics, Gene, RC254-282, Adenosine Triphosphatases, Mechanism (biology), Inhibitors, Cofactors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Chromatin, Cell biology, Oncology, Tumor progression, Tumor immunology, Carcinogenesis, Transcription complexes, Transcription Factors |
| الوصف: | Disordered chromatin remodeling regulation has emerged as an essential driving factor for cancers. Imitation switch (ISWI) family are evolutionarily conserved ATP-dependent chromatin remodeling complexes, which are essential for cellular survival and function through multiple genetic and epigenetic mechanisms. Omics sequencing and a growing number of basic and clinical studies found that ISWI family members displayed widespread gene expression and genetic status abnormalities in human cancer. Their aberrant expression is closely linked to patient outcome and drug response. Functional or componential alteration in ISWI-containing complexes is critical for tumor initiation and development. Furthermore, ISWI-non-coding RNA regulatory networks and some non-coding RNAs derived from exons of ISWI member genes play important roles in tumor progression. Therefore, unveiling the transcriptional regulation mechanism underlying ISWI family sparked a booming interest in finding ISWI-based therapies in cancer. This review aims at describing the current state-of-the-art in the role of ISWI subunits and complexes in tumorigenesis, tumor progression, immunity and drug response, and presenting deep insight into the physiological and pathological implications of the ISWI transcription machinery in cancers. |
| اللغة: | English |
| تدمد: | 1756-9966 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c491e26a323094518aa9997213d1acTest https://doaj.org/article/1996e52a8be5453980dd1016d7d48a5dTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....70c491e26a323094518aa9997213d1ac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17569966 |
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