Moderate weight change following diabetes diagnosis and 10 year incidence of cardiovascular disease and mortality
| العنوان: | Moderate weight change following diabetes diagnosis and 10 year incidence of cardiovascular disease and mortality |
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| المؤلفون: | Gráinne H. Long, Simon J. Griffin, Greg Irving, Clare E. Boothby, Jean Strelitz, Matthew J.L. Hare, Amy L Ahern, Nicholas J. Wareham |
| المساهمون: | Strelitz, Jean [0000-0003-4051-6944], Apollo - University of Cambridge Repository |
| المصدر: | Diabetologia |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, Weight loss, medicine.medical_specialty, Epidemiology, Denmark, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, Weight Gain, Article, Diabetes Complications, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Diabetes mellitus, Internal medicine, Pragmatic Clinical Trials as Topic, Internal Medicine, medicine, Cluster Analysis, Humans, Netherlands, Proportional Hazards Models, Proportional hazards model, business.industry, Incidence, Incidence (epidemiology), Diabetes, Body Weight, Remission Induction, Weight change, Cardiovascular disease, medicine.disease, 3. Good health, Observational Studies as Topic, Treatment Outcome, 030104 developmental biology, Diabetes Mellitus, Type 2, England, Social Class, Cardiovascular Diseases, Regression Analysis, medicine.symptom, business, Weight gain, Follow-Up Studies, Cohort study |
| الوصف: | Aims/hypothesis Adults with type 2 diabetes are at high risk of developing cardiovascular disease (CVD). Evidence of the impact of weight loss on incidence of CVD events among adults with diabetes is sparse and conflicting. We assessed weight change in the year following diabetes diagnosis and estimated associations with 10 year incidence of CVD events and all-cause mortality. Methods In a cohort analysis among 725 adults with screen-detected diabetes enrolled in the Anglo–Danish–Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care (ADDITION)–Cambridge trial, we estimated HRs for weight change in the year following diabetes diagnosis and 10 year incidence of CVD (n = 99) and all-cause mortality (n = 95) using Cox proportional hazards regression. We used linear regression to estimate associations between weight loss and CVD risk factors. Models were adjusted for age, sex, baseline BMI, smoking, occupational socioeconomic status, cardio-protective medication use and treatment group. Results Loss of ≥5% body weight in the year following diabetes diagnosis was associated with improvements in HbA1c and blood lipids and a lower hazard of CVD at 10 years compared with maintaining weight (HR 0.52 [95% CI 0.32, 0.86]). The associations between weight gain vs weight maintenance and CVD (HR 0.41 [95% CI 0.15, 1.11]) and mortality (HR 1.63 [95% CI 0.83, 3.19]) were less clear. Conclusions/interpretation Among adults with screen-detected diabetes, loss of ≥5% body weight during the year after diagnosis was associated with a lower hazard of CVD events compared with maintaining weight. These results support the hypothesis that moderate weight loss may yield substantial long-term CVD reduction, and may be an achievable target outside of specialist-led behavioural treatment programmes. Electronic supplementary material The online version of this article (10.1007/s00125-019-4886-1) contains peer-reviewed but unedited supplementary material, which is available to authorised users. |
| وصف الملف: | application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| تدمد: | 1432-0428 0012-186X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c1cc7723f1dc6a06fb5c5073682050Test https://doi.org/10.1007/s00125-019-4886-1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....70c1cc7723f1dc6a06fb5c5073682050 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320428 0012186X |
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