Temporal Changes in the Cerebrospinal Fluid Level of Hypocretin-1 and Histamine in Narcolepsy
| العنوان: | Temporal Changes in the Cerebrospinal Fluid Level of Hypocretin-1 and Histamine in Narcolepsy |
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| المؤلفون: | Elisa Evangelista, Lucie Barateau, Régis Lopez, Yves Dauvilliers, Isabelle Jaussent, Philippe Robert, Sofiene Chenini |
| المساهمون: | Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Département de neurologie [Montpellier], Hôpital Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Université de Montpellier (UM), Bioprojet-Biotech, Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM) |
| المصدر: | Sleep SLEEP SLEEP, American Academy of Sleep Medicine, 2017, 40 (1), ⟨10.1093/sleep/zsw010⟩ |
| بيانات النشر: | Oxford University Press, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Change over time, Adult, Male, medicine.medical_specialty, Time Factors, Cataplexy, hypocretin/orexin, Adolescent, HYPOCRETIN 1, narcolepsy, Human leukocyte antigen, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cerebrospinal fluid, Physiology (medical), Internal medicine, mental disorders, medicine, HLA-DQ beta-Chains, Humans, Child, ComputingMilieux_MISCELLANEOUS, Orexins, cataplexy, Histocompatibility Testing, Methylhistamines, Middle Aged, medicine.disease, 3. Good health, histamine, 030104 developmental biology, Endocrinology, chemistry, Biomarker (medicine), [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Original Article, Female, Neurology (clinical), medicine.symptom, Psychology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery, Histamine, Biomarkers, Narcolepsy |
| الوصف: | Study Objectives: To follow the temporal changes of cerebrospinal fluid (CSF) biomarker levels in narcoleptic patients with unexpected hypocretin level at referral. Methods: From 2007 to 2015, 170 human leukocyte antigen (HLA) DQB1*06:02-positive patients with primary narcolepsy and definite (n = 155, 95 males, 60 females, 36 children) or atypical cataplexy (n = 15, 4 males, 3 children) were referred to our center. Cerebrospinal hypocretin deficiency was found in 95.5% and 20% of patients with definitive and atypical cataplexy, respectively. CSF hypocretin-1 (n = 6) and histamine/tele-methylhistamine (n = 5) levels were assessed twice (median interval: 14.4 months) in four patients with definite and in two with atypical cataplexy and hypocretin level greater than 100 pg/mL at baseline. Results: CSF hypocretin levels decreased from normal/intermediate to undetectable levels in three of the four patients with definite cataplexy and remained stable in the other (>250 pg/mL). Hypocretin level decreased from 106 to 27 pg/mL in one patient with atypical cataplexy, and remained stable in the other (101 and 106 pg/mL). CSF histamine and tele-methylhistamine levels remained stable, but for one patient showing increased frequency of cataplexy and a strong decrease (−72.5%) of tele-methylhistamine levels several years after disease onset. No significant association was found between relative or absolute change in hypocretin level and demographic/clinical features. Conclusions: These findings show that in few patients with narcolepsy with cataplexy, symptoms and CSF marker levels can change over time. In these rare patients with cataplexy without baseline hypocretin deficiency, CSF markers should be monitored over time with potential for immune therapies in early stages to try limiting hypocretin neuron loss. |
| اللغة: | English |
| تدمد: | 1550-9109 0161-8105 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706392ecdd02cd2e77244c6f201fe578Test http://europepmc.org/articles/PMC5806580Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....706392ecdd02cd2e77244c6f201fe578 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15509109 01618105 |
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