Correlation of disease severity with body weight and high fat diet in the FATZO/Pco mouse
| العنوان: | Correlation of disease severity with body weight and high fat diet in the FATZO/Pco mouse |
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| المؤلفون: | Richard G. Peterson, Karen M. Zimmerman, M. Dodson Michael, Bria L. Sneed, Paul J. Emmerson, Brian A. Droz, Charles V. Jackson, Tamer Coskun |
| المصدر: | PLoS ONE, Vol 12, Iss 6, p e0179808 (2017) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Leptin, Blood Glucose, Male, Physiology, medicine.medical_treatment, Peptide Hormones, Type 2 diabetes, Biochemistry, Fats, Eating, Mice, 0302 clinical medicine, Endocrinology, Hyperinsulinemia, Medicine and Health Sciences, Medicine, Insulin, 2. Zero hunger, Multidisciplinary, Organic Compounds, Monosaccharides, Animal Models, Lipids, 3. Good health, Chemistry, Physiological Parameters, Experimental Organism Systems, Physical Sciences, medicine.symptom, Research Article, medicine.medical_specialty, Offspring, Science, Carbohydrates, 030209 endocrinology & metabolism, Mouse Models, Research and Analysis Methods, Diet, High-Fat, 03 medical and health sciences, Insulin resistance, Model Organisms, Diabetes mellitus, Internal medicine, Animals, Obesity, Pancreas, Nutrition, Diabetic Endocrinology, business.industry, Body Weight, Organic Chemistry, Chemical Compounds, Biology and Life Sciences, medicine.disease, Hormones, Diet, 030104 developmental biology, Glucose, Diabetes Mellitus, Type 2, business, Weight gain |
| الوصف: | Obesity in many current pre-clinical animal models of obesity and diabetes is mediated by monogenic mutations; these are rarely associated with the development of human obesity. A new mouse model, the FATZO mouse, has been developed to provide polygenic obesity and a metabolic pattern of hyperglycemia and hyperinsulinemia, that support the presence of insulin resistance similar to metabolic disease in patients with insulin resistance/type 2 diabetes. The FATZO mouse resulted from a cross of C57BL/6J and AKR/J mice followed by selective inbreeding for obesity, increased insulin and hyperglycemia. Since many clinical studies have established a close link between higher body weight and the development of type 2 diabetes, we investigated whether time to progression to type 2 diabetes or disease severity in FATZO mice was dependent on weight gain in young animals. Our results indicate that lighter animals developed metabolic disturbances much slower and to a lesser magnitude than their heavier counterparts. Consumption of a diet containing high fat, accelerated weight gain in parallel with disease progression. A naturally occurring and significant variation in the body weight of FATZO offspring enables these mice to be identified as low, mid and high body weight groups at a young age. These weight groups remain into adulthood and correspond to slow, medium and accelerated development of type 2 diabetes. Thus, body weight inclusion criteria can optimize the FATZO model for studies of prevention, stabilization or treatment of type 2 diabetes. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff96d25ea08c7654451bfe234ee4c5aTest https://doaj.org/article/bb9f14c1cae741f99f99a57996878039Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6ff96d25ea08c7654451bfe234ee4c5a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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