Immunopathogenic Mechanisms and Novel Immune-Modulated Therapies in Rheumatoid Arthritis
| العنوان: | Immunopathogenic Mechanisms and Novel Immune-Modulated Therapies in Rheumatoid Arthritis |
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| المؤلفون: | Shyi-Jou Chen, Chih-Fen Hu, Kai-Chen Wang, Gu-Jiun Lin, Jing-Wun Chen, Chia-Ning Chang, Wan-Fu Hsu, Huey-Kang Sytwu, Chiung-Hsi Tien, Hueng-Chuen Fan |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 20, Iss 6, p 1332 (2019) |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Chemokine, Proteases, Review, Matrix metalloproteinase, Catalysis, rheumatoid factor, lcsh:Chemistry, immunology, Arthritis, Rheumatoid, Immunomodulation, Inorganic Chemistry, 03 medical and health sciences, 0302 clinical medicine, Immune system, disease-modifying, medicine, Humans, Rheumatoid factor, Physical and Theoretical Chemistry, lcsh:QH301-705.5, Molecular Biology, Spectroscopy, Inflammation, 030203 arthritis & rheumatology, Autoimmune disease, biology, business.industry, Organic Chemistry, anticitrullinated peptide antibodies, Antibodies, Monoclonal, autoimmune, General Medicine, antirheumatic drug, medicine.disease, Matrix Metalloproteinases, Computer Science Applications, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Antirheumatic Agents, Rheumatoid arthritis, Immunology, biology.protein, pathology, Chemokines, Antibody, business |
| الوصف: | Rheumatoid arthritis (RA) is a chronic, inflammatory autoimmune disease of unknown etiology. It is characterized by the presence of rheumatoid factor and anticitrullinated peptide antibodies. The orchestra of the inflammatory process among various immune cells, cytokines, chemokines, proteases, matrix metalloproteinases (MMPs), and reactive oxidative stress play critical immunopathologic roles in the inflammatory cascade of the joint environment, leading to clinical impairment and RA. With the growing understanding of the immunopathogenic mechanisms, increasingly novel marked and potential biologic agents have merged for the treatment of RA in recent years. In this review, we focus on the current understanding of pathogenic mechanisms, highlight novel biologic disease-modifying antirheumatic drugs (DMRADs), targeted synthetic DMRADs, and immune-modulating agents, and identify the applicable immune-mediated therapeutic strategies of the near future. In conclusion, new therapeutic approaches are emerging through a better understanding of the immunopathophysiology of RA, which is improving disease outcomes better than ever. |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff528cf97f3511110c0960eefae598dTest https://doi.org/10.3390/ijms20061332Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6ff528cf97f3511110c0960eefae598d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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