Endocrine effects of duodenal–jejunal exclusion in obese patients with type 2 diabetes mellitus
| العنوان: | Endocrine effects of duodenal–jejunal exclusion in obese patients with type 2 diabetes mellitus |
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| المؤلفون: | Daniel Novák, Terezie Pelikanova, P Kaválková, Anna Cinkajzlová, Milos Mraz, Libor Vítek, Vaclav Burda, Zdeňka Lacinová, Marek Benes, Martin Haluzik, Jana Klouckova, Zuzana Vlasáková, Denisa Haluzikova, T. Petr, P Trachta |
| المصدر: | Journal of Endocrinology. 231:11-22 |
| بيانات النشر: | Bioscientifica, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, medicine.medical_specialty, Time Factors, Duodenum, Endocrinology, Diabetes and Metabolism, Bariatric Surgery, 030209 endocrinology & metabolism, Bile Acids and Salts, Duodenal-jejunal bypass liner, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Glucagon-Like Peptide 1, Weight loss, Internal medicine, White blood cell, Weight Loss, medicine, Humans, Obesity, Postoperative Period, Aged, Glycemic, business.industry, Type 2 Diabetes Mellitus, FGF19, Middle Aged, Postprandial Period, Lipids, Fibroblast Growth Factors, Jejunum, Treatment Outcome, medicine.anatomical_structure, Postprandial, Diabetes Mellitus, Type 2, Female, 030211 gastroenterology & hepatology, Blood sugar regulation, medicine.symptom, business |
| الوصف: | Duodenal–jejunal bypass liner (DJBL) is an endoscopically implantable device designed to noninvasively mimic the effects of gastrointestinal bypass operations by excluding the duodenum and proximal jejunum from the contact with ingested food. The aim of our study was to assess the influence of DJBL on anthropometric parameters, glucose regulation, metabolic and hormonal profile in obese patients with type 2 diabetes mellitus (T2DM) and to characterize both the magnitude and the possible mechanisms of its effect. Thirty obese patients with poorly controlled T2DM underwent the implantation of DJBL and were assessed before and 1, 6 and 10months after the implantation, and 3months after the removal of DJBL. The implantation decreased body weight, and improved lipid levels and glucose regulation along with reduced glycemic variability. Serum concentrations of fibroblast growth factor 19 (FGF19) and bile acids markedly increased together with a tendency to restoration of postprandial peak of GLP1. White blood cell count slightly increased and red blood cell count decreased throughout the DJBL implantation period along with decreased ferritin, iron and vitamin B12 concentrations. Blood count returned to baseline values 3months after DJBL removal. Decreased body weight and improved glucose control persisted with only slight deterioration 3months after DJBL removal while the effect on lipids was lost. We conclude that the implantation of DJBL induced a sustained reduction in body weight and improvement in regulation of lipid and glucose. The increase in FGF19 and bile acids levels could be at least partially responsible for these effects. |
| تدمد: | 1479-6805 0022-0795 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f75014dce1f5e2ecd972d6d9002e1baTest https://doi.org/10.1530/joe-16-0206Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6f75014dce1f5e2ecd972d6d9002e1ba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14796805 00220795 |
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